Volume 10 Supplement 1

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR)

Meeting abstracts

Vienna, Austria25-27 November 2010

The trafficking of GPR55 is regulated by the G protein-coupled receptor-associated sorting protein 1

Authors: Julia Kargl, Nariman Balenga, Wolfgang Platzer, Lene Martini, Jennifer Whistler and Maria Waldhoer

Citation: BMC Pharmacology 2010 10(Suppl 1):A1

Content type: Meeting abstract Published on: 16 November 2010
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Effect of rat common carotid artery occlusion on vascular action of adenosine

Authors: Miroslav Radenković, Radmila Stevanović, Marko Stojanović, Mirko Topalović and Milica Stojiljković

Citation: BMC Pharmacology 2010 10(Suppl 1):A2

Content type: Meeting abstract Published on: 16 November 2010
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Resveratrol reduces myofibroblast arrhythmogenicity

Authors: Christian Rosker, Nicolò Salvarani and Stephan Rohr

Citation: BMC Pharmacology 2010 10(Suppl 1):A3

Content type: Meeting abstract Published on: 16 November 2010
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A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids

Authors: Muhammad Faheem Asim, Gerhard Wolber, Mariana Spetea and Helmut Schmidhammer

Citation: BMC Pharmacology 2010 10(Suppl 1):A4

Content type: Meeting abstract Published on: 16 November 2010
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Enhanced fear expression in a psychphathological mouse model of trait anxiety: pharmacological interventions

Authors: Markus Hauschild, Simone B Sartori, Mirjam Bunck, Stefano Gaburro, Rainer Landgraf and Nicolas Singewald

Citation: BMC Pharmacology 2010 10(Suppl 1):A5

Content type: Meeting abstract Published on: 16 November 2010
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The interplay of excitatory and inhibitory coupling modes is crucial for the regulation of neuronal electrical activities by L-type calcium channels

Authors: Petra Geier, Michael Lagler, Stefan Boehm and Helmut Kubista

Citation: BMC Pharmacology 2010 10(Suppl 1):A6

Content type: Meeting abstract Published on: 16 November 2010
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Cross-talk of PGD₂ receptors: the DP receptor modulates signaling and trafficking of CRTH2

Authors: Miriam Sedej, Wolfgang Platzer, Ákos Heinemann and Maria Waldhoer

Citation: BMC Pharmacology 2010 10(Suppl 1):A7

Content type: Meeting abstract Published on: 16 November 2010
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Signalling and function of the human G protein-coupled receptor 55

Authors: Nariman Balenga, Julia Kargl, Ralf Schröder, Ákos Heinemann, Evi Kostenis and Maria Waldhoer

Citation: BMC Pharmacology 2010 10(Suppl 1):A8

Content type: Meeting abstract Published on: 16 November 2010
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Is thymoquinone an antioxidant?

Authors: Katrin Staniek and Lars Gille

Citation: BMC Pharmacology 2010 10(Suppl 1):A9

Content type: Meeting abstract Published on: 16 November 2010
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Toxicity of ascaridole from Chenopodium ambrosioides in mammalian mitochondria

Authors: Lars Gille, Lianet Monzote, Werner Stamberg and Katrin Staniek

Citation: BMC Pharmacology 2010 10(Suppl 1):A10

Content type: Meeting abstract Published on: 16 November 2010
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Concentrative ER export of the serotonin transporter relies exclusively on an interaction with Sec24C

Authors: Sonja Sucic, Ali El-Kasaby, Subhodeep Sarker, Harald H Sitte, Philippe Marin and Michael Freissmuth

Citation: BMC Pharmacology 2010 10(Suppl 1):A11

Content type: Meeting abstract Published on: 16 November 2010
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Long-term regulation of ATP-binding cassette transporters on mRNA and protein level by simvastatin in human rhabdomyosarcoma and neuroblastoma cells

Authors: Bihter Atil, Martin Werner, Evelyn Sieczkowski, Peter Chiba and Martin Hohenegger

Citation: BMC Pharmacology 2010 10(Suppl 1):A12

Content type: Meeting abstract Published on: 16 November 2010
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Interactions of peripheral and central μ opioid systems during emotional stress

Authors: Valentina Bashkatova, Helmut Prast, Alexei Umriukhin and Sergey Sudakov

Citation: BMC Pharmacology 2010 10(Suppl 1):A13

Content type: Meeting abstract Published on: 16 November 2010
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Effects on cell proliferation and EPR spin trapping studies of Abnormal Savda Munziq and its chromatographic subfractions

Authors: Klaus Stolze, Adiljan Ablimit and Alois Strasser

Citation: BMC Pharmacology 2010 10(Suppl 1):A14

Content type: Meeting abstract Published on: 16 November 2010
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Molecular engineering of the TRPC3 pore structure identifies Ca²⁺ permeation through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling

Authors: Michaela Lichtenegger, Hannes Schleifer, Thomas Stockner, Christoph Romanin, Michael Poteser and Klaus Groschner

Citation: BMC Pharmacology 2010 10(Suppl 1):A15

Content type: Meeting abstract Published on: 16 November 2010
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Interaction of manganese with striatal dopamine turnover in human alpha-synuclein transgenic mice

Authors: Tamara M Peneder, Michael Berger, Petra Scholze, Georg Heinze, Johanna Bertl, Jan Bauer, Oleh Hornykiewicz, Eric K Richfield and Christian Pifl

Citation: BMC Pharmacology 2010 10(Suppl 1):A16

Content type: Meeting abstract Published on: 16 November 2010
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A biological target for antiplatelet therapy: the prostaglandin E₂ receptor EP₄

Authors: Sonia Philipose, Martina Ofner, Ákos Heinemann and Rufina Schuligoi

Citation: BMC Pharmacology 2010 10(Suppl 1):A17

Content type: Meeting abstract Published on: 16 November 2010
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The role of the carboxyl terminus in folding of the serotonin transporter

Authors: Ali El-Kasaby, Herwig Just, Harald Sitte, Oliver Kudlacek and Michael Freissmuth

Citation: BMC Pharmacology 2010 10(Suppl 1):A18

Content type: Meeting abstract Published on: 16 November 2010
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Calmodulin kinase II regulates amphetamine-induced reverse transport in the dopamine transporter: implications for the importance of the dopamine transporter in Angelman syndrome

Authors: Thomas Steinkellner, Oliver Kudlacek, Michael Freissmuth, Ype Elgersma and Harald Sitte

Citation: BMC Pharmacology 2010 10(Suppl 1):A19

Content type: Meeting abstract Published on: 16 November 2010
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α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation

Authors: Robert Trondl, Christian R Kowol, Vladimir B Arion, Michael A Jakupec and Bernhard K Keppler

Citation: BMC Pharmacology 2010 10(Suppl 1):A20

Content type: Meeting abstract Published on: 16 November 2010
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The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter

Authors: Subhodeep Sarker, René Weissensteiner, Ilka Steiner, Harald H Sitte, Gerhard F Ecker, Michael Freissmuth and Sonja Sucic

Citation: BMC Pharmacology 2010 10(Suppl 1):A21

Content type: Meeting abstract Published on: 16 November 2010
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4-Methylthioamphetamine (4-MTA) induces mitochondrial-dependent apoptosis in SH-SY5Y cells independently of dopamine and noradrenaline transporters

Authors: Therese Montgomery, Harald Sitte and Gethin McBean

Citation: BMC Pharmacology 2010 10(Suppl 1):A22

Content type: Meeting abstract Published on: 16 November 2010
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A molecular switch between the outer and the inner vestibules of the voltage-gated Na⁺ channel

Authors: René Cervenka, Péter Lukács, Touran Zarrabi, Xaver Koenig, Agnés Mike, Karlheinz Hilber and Hannes Todt

Citation: BMC Pharmacology 2010 10(Suppl 1):A23

Content type: Meeting abstract Published on: 16 November 2010
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The permanently charged lidocaine analogue QX222 acts as a blocker from the intracellular side and as an inactivation modulator from the extracellular side in a mutant Na_V1.4 channel

Authors: Péter Lukács, René Cervenka, Xaver Koenig, Agnés Mike, Touran Zarrabi, Karlheinz Hilber and Hannes Todt

Citation: BMC Pharmacology 2010 10(Suppl 1):A24

Content type: Meeting abstract Published on: 16 November 2010
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Altered sodium channel function in dystrophin/utrophin-deficient cardiomyocytes

Authors: Xaver Koenig, Agnes Mike, Markus Mille, René Cervenka, Péter Lukács, Katrin Nagl, Xuan Bach Dang, Hannes Todt, Reginald E Bittner and Karlheinz Hilber

Citation: BMC Pharmacology 2010 10(Suppl 1):A25

Content type: Meeting abstract Published on: 16 November 2010
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The interactome of the A_2A adenosine receptor in vitro and in vivo

Authors: Christian Bergmayr, Christian Nanoff, Oliver Kudlacek and Christian Gruber

Citation: BMC Pharmacology 2010 10(Suppl 1):A26

Content type: Meeting abstract Published on: 16 November 2010
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Conformation of membrane-inserted P-glycoprotein

Authors: Thomas Stockner, Harald H Sitte and Peter Chiba

Citation: BMC Pharmacology 2010 10(Suppl 1):A27

Content type: Meeting abstract Published on: 16 November 2010
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Selective serotonin reuptake inhibitor-induced cell death: in search of a mechanism

Authors: Christina Glöckel, Christoph Minichsdorfer, Gerhard F Ecker and Michael Freissmuth

Citation: BMC Pharmacology 2010 10(Suppl 1):A28

Content type: Meeting abstract Published on: 16 November 2010
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The pulmonary microvascular endothelial barrier function is controlled by the PGE₂-EP₄ signaling axis

Authors: Viktória Kónya, Andreas Üllen, Eva M Sturm, Petra Luschnig, Wolfgang Sattler and Ákos Heinemann

Citation: BMC Pharmacology 2010 10(Suppl 1):A29

Content type: Meeting abstract Published on: 16 November 2010
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Tracking the A_2A adenosine receptor

Authors: Patrick Thurner, Simon Keuerleber, Ingrid Gsandtner, Michael Freissmuth and Jürgen Zezula

Citation: BMC Pharmacology 2010 10(Suppl 1):A30

Content type: Meeting abstract Published on: 16 November 2010
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Luminescence resonance energy transfer-based intramolecular distance measurements in leucine transporter from Aquifex aeolicus

Authors: Azmat Sohail, Peggy Stolt-Bergner, Gerhard F Ecker, Michael Freissmuth, Harald Sitte and Walter Sandtner

Citation: BMC Pharmacology 2010 10(Suppl 1):A31

Content type: Meeting abstract Published on: 16 November 2010
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Endogenous dynorphin in emotional control and stress response revisited

Authors: Christoph Schwarzer, Christian Lutsch, Eduard Schunk, Iris Kastenberger and Herbert Herzog

Citation: BMC Pharmacology 2010 10(Suppl 1):A32

Content type: Meeting abstract Published on: 16 November 2010
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Neuropeptide Y in the basolateral amygdala modulates the acquisition of conditioned fear

Authors: Ramon O Tasan, Dilip Verma, Herbert Herzog and Günther Sperk

Citation: BMC Pharmacology 2010 10(Suppl 1):A33

Content type: Meeting abstract Published on: 16 November 2010
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Fear learning triggers structural changes at GABAergic synapses in the basal amygdala

Authors: Yu Kasugai, Markus Hauschild, Werner Sieghart, Ryuichi Shigemoto, Nicolas Singewald and Francesco Ferraguti

Citation: BMC Pharmacology 2010 10(Suppl 1):A34

Content type: Meeting abstract Published on: 16 November 2010
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Short-chain methotrexate polyglutamate MTXPG2 as outcome parameter in rheumatoid arthritis

Authors: Eva-Luise Hobl, Bernd Jilma, Ludwig Erlacher and Robert Mader

Citation: BMC Pharmacology 2010 10(Suppl 1):A35

Content type: Meeting abstract Published on: 16 November 2010
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Teicoplanin pharmacokinetics during albumin dialysis

Authors: Stefan Weiler, Gerda Falkensammer, Christoph Seger, Michael Joannidis and Romuald Bellmann

Citation: BMC Pharmacology 2010 10(Suppl 1):A36

Content type: Meeting abstract Published on: 16 November 2010
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Endotoxin-induced microparticle formation is subject to tolerance development in humans

Authors: Daniel Nguyen, Stefan Weisshaar and Michael Wolzt

Citation: BMC Pharmacology 2010 10(Suppl 1):A37

Content type: Meeting abstract Published on: 16 November 2010
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Does VEGF polymorphism play a role in the treatment success with VEGF inhibitors in patients with CNV?

Authors: Agnes Boltz, Günther Weigert, Stefan Palkovits, Manuel Ruiß, Martin Weger, Yosuf El-Shabrawi, Gerhard Garhöfer, Jost Jonas and Leopold Schmetterer

Citation: BMC Pharmacology 2010 10(Suppl 1):A38

Content type: Meeting abstract Published on: 16 November 2010
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Antimicrobial activity of antibiotics in urine under different physiological conditions

Authors: Angela Burian, Zeynep Erdogan, Mohammad Manafi and Markus Zeitlinger

Citation: BMC Pharmacology 2010 10(Suppl 1):A39

Content type: Meeting abstract Published on: 16 November 2010
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The influence of lutein supplementation on macular pigment optical density in patients with dry AMD compared with healthy control subjects

Authors: Semira Kaya, Günther Weigert, Nikolaus Dragostinoff, René Werkmeister, Berthold Pemp, Stefan Sacu, Gerhard Garhöfer, Ursula Schmidt-Erfurth and Leopold Schmetterer

Citation: BMC Pharmacology 2010 10(Suppl 1):A40

Content type: Meeting abstract Published on: 16 November 2010
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BEZ235 impairs gastric cancer growth by inhibition of PI3K/mTOR in vitro and in vivo

Authors: Thorsten Füreder, Thomas Wanek, Pamina Pflegerl, Agnes Jaeger-Lansky, Doris Hoeflmayer, Sabine Strommer, Claudia Kuntner, Markus Müller, Oliver Langer and Volker Wacheck

Citation: BMC Pharmacology 2010 10(Suppl 1):A41

Content type: Meeting abstract Published on: 16 November 2010
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Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo

Authors: Johannes Werzowa, Stefan Koehrer, Sabine Strommer, Daniel Cejka, Thorsten Füreder and Volker Wacheck

Citation: BMC Pharmacology 2010 10(Suppl 1):A42

Content type: Meeting abstract Published on: 16 November 2010
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Thrombus formation is not pH-dependent

Authors: Stefan Weisshaar, Ghazaleh Gouya and Michael Wolzt

Citation: BMC Pharmacology 2010 10(Suppl 1):A43

Content type: Meeting abstract Published on: 16 November 2010
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Inhibition of tissue factor pathway inhibitor (TFPI) by ARC19499 improves clotting of hemophiliac blood

Authors: Monika E Gorczyca, Bernd Jilma, Christoph Male, Sylvia Reitter, James C Gilbert and Ingrid Pabinger

Citation: BMC Pharmacology 2010 10(Suppl 1):A44

Content type: Meeting abstract Published on: 16 November 2010
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Tissue pharmacokinetics of individual macrolides support observed differences in development of bacterial resistance

Authors: Shaip Krasniqi, Peter Matzneller, Martina Kinzig, Sven Hüttner, Fritz Sörgel, Markus Müller and Markus Zeitlinger

Citation: BMC Pharmacology 2010 10(Suppl 1):A45

Content type: Meeting abstract Published on: 16 November 2010
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Small-animal PET evaluation of [¹¹C]MC113 as a PET tracer for P-glycoprotein

Authors: Severin Mairinger, Nicola A Colabufo, Thomas Wanek, Claudia Kuntner, Johann Stanek, Thomas Erker, Mariangela Cantore, Francesco Berardi, Roberto Perrone, Markus Müller and Oliver Langer

Citation: BMC Pharmacology 2010 10(Suppl 1):A46

Content type: Meeting abstract Published on: 16 November 2010
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Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[¹¹C]verapamil PET

Authors: Martin Bauer, Markus Zeitlinger, Peter Matzneller, Johann Stanek, Edith Lackner, Wolfgang Wadsak, Markus Müller and Oliver Langer

Citation: BMC Pharmacology 2010 10(Suppl 1):A47

Content type: Meeting abstract Published on: 16 November 2010
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Heterogeneous penetration of cefpirome and moxifloxacin into abscesses after simultaneous administration in humans

Authors: Robert Sauermann, Thomas Feurstein, Rudolf Karch, Andreas Püspök, Herbert Langenberger, Walter Jäger, Michaela Böhmdorfer, Thomas Wild, Stefan Winkler, Maria C Kjellsson and Markus Zeitlinger

Citation: BMC Pharmacology 2010 10(Suppl 1):A48

Content type: Meeting abstract Published on: 16 November 2010
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16th Scientific Symposium of the Austrian Pharmacological Society (APHAR)

Meeting abstracts

BMC Pharmacology