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Open Access

Endogenous dynorphin in emotional control and stress response revisited

  • Christoph Schwarzer1Email author,
  • Christian Lutsch1,
  • Eduard Schunk1,
  • Iris Kastenberger1 and
  • Herbert Herzog2
BMC Pharmacology201010(Suppl 1):A32

https://doi.org/10.1186/1471-2210-10-S1-A32

Published: 16 November 2010

Background

We recently demonstrated a clearly anxiolytic phenotype of prodynorphin-deficient (dynKO) mice on the C57bl/6N background. However, other groups observed a less prominent and partially paradigm-dependent anxiogenic phenotype or even anxiogenic phenotype of other dynKO mice. Therefore we backcrossed our dynKO mice onto the balb/c background and evaluated their anxiety-related behaviour.

Methods

In this study, we investigated anxiety and stress-related behaviour of germ-line prodynorphin knockout (dynKO) mice. Behavioural data were complemented by measurement of corticosterone serum levels.

Results

Male dynKO mice exhibited about 2-fold ambulation in the open field center and intermediate areas. DynKO mice showed also longer distance travelled (2-fold) and more time spent on open arms of the elevated plus maze test. Significantly higher numbers of mice entering the open lit area in the light-dark test were observed in dynKO as compared to wild-type mice. As observed on the C57bl/6N background, only minor changes were observed in the stress-coping abilities measured in the tail suspension and forced swim tests. A reduction of basal corticosterone levels was observed in dyn-KO mice.

Conclusions

Taken together our data support the anxiogenic effects of endogenous dynorphin as observed on the C57bl/6N background. However, the phenotype is less clear on the balb/c background.

Declarations

Acknowledgements

This project was supported by the Austrian Science Fund (P20107).

Authors’ Affiliations

(1)
Institute of Pharmacology, Innsbruck Medical University
(2)
Neuroscience Research Program, Garvan Institute of Medical Research

Copyright

© Schwarzer et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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