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Endogenous dynorphin in emotional control and stress response revisited
BMC Pharmacology volume 10, Article number: A32 (2010)
We recently demonstrated a clearly anxiolytic phenotype of prodynorphin-deficient (dynKO) mice on the C57bl/6N background. However, other groups observed a less prominent and partially paradigm-dependent anxiogenic phenotype or even anxiogenic phenotype of other dynKO mice. Therefore we backcrossed our dynKO mice onto the balb/c background and evaluated their anxiety-related behaviour.
In this study, we investigated anxiety and stress-related behaviour of germ-line prodynorphin knockout (dynKO) mice. Behavioural data were complemented by measurement of corticosterone serum levels.
Male dynKO mice exhibited about 2-fold ambulation in the open field center and intermediate areas. DynKO mice showed also longer distance travelled (2-fold) and more time spent on open arms of the elevated plus maze test. Significantly higher numbers of mice entering the open lit area in the light-dark test were observed in dynKO as compared to wild-type mice. As observed on the C57bl/6N background, only minor changes were observed in the stress-coping abilities measured in the tail suspension and forced swim tests. A reduction of basal corticosterone levels was observed in dyn-KO mice.
Taken together our data support the anxiogenic effects of endogenous dynorphin as observed on the C57bl/6N background. However, the phenotype is less clear on the balb/c background.
This project was supported by the Austrian Science Fund (P20107).
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Schwarzer, C., Lutsch, C., Schunk, E. et al. Endogenous dynorphin in emotional control and stress response revisited. BMC Pharmacol 10, A32 (2010). https://doi.org/10.1186/1471-2210-10-S1-A32
- Corticosterone Level
- Field Center
- Maze Test
- Emotional Control
- Corticosterone Serum