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Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients
BMC Pharmacology volume 7, Article number: P18 (2007)
Altered modulation of cGMP levels in brain seems to be responsible for the impairment of some types of cognitive function . The homeostasis of cGMP is also strongly altered in blood in patients with liver disease, who show increased plasma cGMP but reduced cGMP content in lymphocytes . Activation of soluble guanylate cyclase by NO is also altered in lymphocytes of patients with liver cirrhosis . This suggests that alterations in cGMP homeostasis in blood could reflect the alterations in brain and be therefore associated with the appearance of minimal hepatic encephalopathy (MHE). The aim was to assess whether there is a correlation between the alterations in different parameters involved in modulation of cGMP levels and the presence of MHE.
We studied in 46 patients with liver cirrhosis and 26 controls the performance in the PHES battery of psychometric tests, critical flicker frequency (CFF), cGMP in plasma and lymphocytes, activation of guanylate cyclase by NO in lymphocytes, ammonia, nitric oxide metabolites and atrial natriuretic peptide (ANP).
Activation of guanylate cyclase by NO in lymphocytes and cGMP in plasma were higher and CFF lower in patients with than without MHE. Ammonia, ANP and metabolites of nitric oxide were higher in patients than in controls but were no different in patients with or without MHE (Figures 1, 2, 3, 4; Table 1).
Alteration in activation of guanylate cyclase by NO in lymphocytes correlates with PHES performance, CFF and ammonia levels (Table 2). This suggests that altered modulation of guanylate cyclase by NO in lymphocytes would reflect a parallel alteration in brain occurring in patients with MHE that would be involved in their cognitive impairment.
Erceg S, Monfort P, Hernandez-Viadel M, Llansola M, Montoliu C, Felipo V: Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain. Brain Res. 2005, 1036: 115-121. 10.1016/j.brainres.2004.12.045.
Montoliu C, Kosenko E, Del Olmo JA, Serra MA, Rodrigo JM, Felipo V: Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis. Liver Int. 2005, 25: 787-795. 10.1111/j.1478-3231.2005.01066.x.
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Felipo, V., Piedrafita, B., Urios, A. et al. Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients. BMC Pharmacol 7, P18 (2007). https://doi.org/10.1186/1471-2210-7-S1-P18
- Nitric Oxide
- Liver Disease
- Cognitive Impairment
- Liver Cirrhosis
- Hepatic Encephalopathy