Table 1 Values of the different parameters analyzed in controls and in patients.
PARAMETERS | CONTROLS Media ± SD (n) | PATIENTS WITHOUT MHE p vs. Control | PATIENTS WITH MHE P vs. control | PATIENTS WITH MHE p vs. without MHE |
|---|---|---|---|---|
Basal cGMP in lymphocytes (pmoles/mg prot) | 0.47 ± 0.15 (n = 26) | 0.049 ± 0.02 (n = 22) p < 0.001 ** | 0.025 ± 0.015 (n = 12) p < 0.001 ** | p > 0.05 |
SNAP-induced cGMP increase (fold) | 12 ± 6 (n = 26) | 31 ± 15 (n = 23) p < 0.001 ** | 47 ± 18 (n = 12) p < 0.001 *** | p < 0.05 * |
cGMP in Plasma (μM) | 4.4 ± 1.7 (n = 17) | 12 ± 4 (n = 24) p < 0.001 ** | 18 ± 4 (n = 12) p < 0.001 *** | p < 0.001 ** |
Nitrates + Nitrites (μM) | 22 ± 9 (n = 26) | 31 ± 13 (n = 31) p < 0.05* | 38 ± 14 (n = 13) p < 0.001 *** | p = 0.09 (ns) |
ANP in Plasma (pg/ml) | 78 ± 13 (n = 13) | 119 ± 25 (n = 14) p < 0.001 ** | 140 ± 50 (n = 9) p < 0.001** | p = 0.193 (ns) |
Ammonia concentration (μM) | 76 ± 30 (n = 23) | 156 ± 86 (n = 23) p = 0.001 *** | 151 ± 51 (n = 9) p < 0.001 *** | p = 0.89 (ns) |
CFF (Hz) | 46 ± 3 (n = 26) | 41 ± 3 (n = 24) p < 0.001 *** | 33 ± 4 (n = 15) p < 0.001 ** | p < 0.001 ** |
SCORE PHES | -0.15 ± 1 (n = 26) | -0.57 ± 1 (n = 31) | -8.7 ± 2.1 (n = 15) | p < 0.001 ** |
Age | 43 ± 12 | 50 ± 8 | 55 ± 11 | p > 0.05 (ns) |