- Poster presentation
- Open Access
NO-donors induce cross talk between cGMP and cAMP in signalling to human atrial L-type Ca2+ current
© Rozmaritsa et al; licensee BioMed Central Ltd. 2011
- Published: 1 August 2011
- Guanylate Cyclase
- PDE2 Inhibition
- cAMP Signalling
- Soluble Guanylate Cyclase
Experiments were performed on human biopsy tissue from 62 patients in sinus rhythm. ICa,L was measured with whole-cell voltage-clamp technique.
We conclude that in human atrial cardiomyocytes NO-donors stimulate production of cGMP with further cross-talk to cAMP via PDE2 and PDE3.
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