Volume 11 Supplement 1

5th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

Halle, Germany24-26 June 2011

Page 1 of 3

Designer natriuretic peptides for heart failure: advanced in clinical development

Authors: John Burnett Jr.

Citation: BMC Pharmacology 2011 11(Suppl 1):O1

Content type: Oral presentation

Published on: 1 August 2011
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New clinical results with sGC stimulators

Authors: Jürgen Behr

Citation: BMC Pharmacology 2011 11(Suppl 1):O2

Content type: Oral presentation

Published on: 1 August 2011
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LCZ696, an angiotensin receptor neprilysin inhibitor (ARNI): clinical development in heart failure and hypertension

Authors: Martin P Lefkowitz

Citation: BMC Pharmacology 2011 11(Suppl 1):O3

Content type: Oral presentation

Published on: 1 August 2011
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Biomarkers in kidney and heart disease

Authors: Alan S Maisel

Citation: BMC Pharmacology 2011 11(Suppl 1):O4

Content type: Oral presentation

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Human genetics, natriuretic peptides and hypertension

Authors: Christopher Newton-Cheh

Citation: BMC Pharmacology 2011 11(Suppl 1):O5

Content type: Oral presentation

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Benefits of PDE5 inhibition in patients with diastolic heart failure

Authors: Marco Guazzi

Citation: BMC Pharmacology 2011 11(Suppl 1):O6

Content type: Oral presentation

Published on: 1 August 2011
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Nitric oxide scavenging by red cell microparticles and cell free hemoglobin as a mechanism for hemolytic diseases and the red blood cell storage lesion

Authors: Marc T Gladwin

Citation: BMC Pharmacology 2011 11(Suppl 1):O7

Content type: Oral presentation

Published on: 1 August 2011
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Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology

Authors: Michael S Wolin, Boon Hwa Neo, Dhara Patel, Raed Alhawaj, Sharath Kandhi and Mansoor Ahmad

Citation: BMC Pharmacology 2011 11(Suppl 1):O8

Content type: Oral presentation

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Nitric oxide-independent stimulation of soluble guanylate cyclase attenuates pulmonary fibrosis

Authors: Oleg V Evgenov, Lin Zou, Ming Zhang, Mari Mino-Kenudson, Eugene J Mark, Emmanuel S Buys, Michael J Raher, Yan Li, Yan Feng, Rosemary C Jones, Johannes-Peter Stasch and Wei Chao

Citation: BMC Pharmacology 2011 11(Suppl 1):O9

Content type: Oral presentation

Published on: 1 August 2011
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Molecular aspects of sGC regulation

Authors: Michael A Marletta, Eric S Underbakke and Nathaniel B Fernhoff

Citation: BMC Pharmacology 2011 11(Suppl 1):O10

Content type: Oral presentation

Published on: 1 August 2011
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Structural insights into sGC activation by different activators

Authors: Focco van den Akker, Faye Martin, Vijay Kumar, Xiaolei Ma, Johannes-Peter Stasch, Martina Schaefer, Padmamalini Baskaran, Annie Beuve and Pete W van Dunten

Citation: BMC Pharmacology 2011 11(Suppl 1):O11

Content type: Oral presentation

Published on: 1 August 2011
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PKA: assembly of dynamic macromolecular signaling

Authors: Susan S Taylor, Ronit Ilouz, Manjula Darshi, Ganapathy Sarma, Alexandr Kornev and Ping Zhang

Citation: BMC Pharmacology 2011 11(Suppl 1):O12

Content type: Oral presentation

Published on: 1 August 2011
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Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication

Authors: Wolfgang R Dostmann and Brent W Osborne

Citation: BMC Pharmacology 2011 11(Suppl 1):O13

Content type: Oral presentation

Published on: 1 August 2011
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The crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding

Authors: Jeong Joo Kim, Darren E Casteel, Gilbert Huang, Taek Hun Kwon, Ronnie Kuo Ren, Peter Zwart, Jeffrey J Headd, Nicholas Gene Brown, Dar-Chone Chow, Timothy Palzkill and Choel Kim

Citation: BMC Pharmacology 2011 11(Suppl 1):O14

Content type: Oral presentation

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Characterization of mice with a deletion of protein kinase G type I in cardiomyocytes and the effect on cardioprotection through either postconditioning or mitochondria-targeted S-nitrosothiol

Authors: Carmen Methner, Robert Lukowski, Franz Hofmann, Michael Murphy and Thomas Krieg

Citation: BMC Pharmacology 2011 11(Suppl 1):O15

Content type: Oral presentation

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Effects of long-term proBNP cardiac gene delivery in experimental hypertensive heart disease

Authors: Alessandro Cataliotti, Jason M Tonne, Guido Boerrigter, Salvatore Mangiafico, John C Burnett and Yasuhiro Ikeda

Citation: BMC Pharmacology 2011 11(Suppl 1):O16

Content type: Oral presentation

Published on: 1 August 2011
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Vascular and renal function of cGMP signalling

Authors: Jens Schlossmann, Elisabeth Schinner, Matthias Desch, Bernhard Hieke, Petra Rothammer, Katharina Salb and Andrea Schramm

Citation: BMC Pharmacology 2011 11(Suppl 1):O17

Content type: Oral presentation

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cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2

Authors: Eiki Takimoto

Citation: BMC Pharmacology 2011 11(Suppl 1):O18

Content type: Oral presentation

Published on: 1 August 2011
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cGMP kinase I, cardiac hypertrophy and PDE inhibition

Authors: Enrico Patrucco, Robert Lukowski, Sergei Rybalkin, Joe Beavo and Franz Hofmann

Citation: BMC Pharmacology 2011 11(Suppl 1):O19

Content type: Oral presentation

Published on: 1 August 2011
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Molecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse?

Authors: Candace M Adamo, Dao-Fu Dai, Justin M Percival, Elina Minami, Monte S Willis, Enrico Patrucco, Sergei D Rybalkin, Stanley C Froehner and Joseph A Beavo

Citation: BMC Pharmacology 2011 11(Suppl 1):O20

Content type: Oral presentation

Published on: 1 August 2011
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NO signalling in synaptic transmission

Authors: Doris Koesling, Angela Neitz, Thomas Mittmann and Evanthia Mergia

Citation: BMC Pharmacology 2011 11(Suppl 1):O21

Content type: Oral presentation

Published on: 1 August 2011
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High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIα knock-in mouse

Authors: Oleksandra Prysyazhna, Olena Rudyk and Philip Eaton

Citation: BMC Pharmacology 2011 11(Suppl 1):O22

Content type: Oral presentation

Published on: 1 August 2011
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Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide

Authors: Takaaki Akaike

Citation: BMC Pharmacology 2011 11(Suppl 1):O23

Content type: Oral presentation

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Src activation by cGMP/PKG II in osteoblasts: characterization of a mechano-sensitive signalling complex

Authors: Hema Rangaswami, Raphaela Schwappacher, Nisha Marathe, Darren E Casteel, Bodo Haas, Alexander Pfeifer, Sanford Shattil, Gerry Boss and Renate B Pilz

Citation: BMC Pharmacology 2011 11(Suppl 1):O24

Content type: Oral presentation

Published on: 1 August 2011
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cGMP/cGKI signaling in peripheral vascular smooth muscle does not involve TrpC3 or TrpC6 channels

Authors: Jörg Wegener, Florian Loga, Katrin Domes and Franz Hofmann

Citation: BMC Pharmacology 2011 11(Suppl 1):O25

Content type: Oral presentation

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Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of rattlesnake corpus cavernosum

Authors: Gilberto De Nucci

Citation: BMC Pharmacology 2011 11(Suppl 1):O26

Content type: Oral presentation

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Regulation of vascular growth and tone by hydrogen sulfide

Authors: Andreas Papapetropoulos

Citation: BMC Pharmacology 2011 11(Suppl 1):O27

Content type: Oral presentation

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A novel pathway of cGMP

Authors: Michaela Kuhn, Beatrice Dankworth, Martin Kruse, Michael Hartmann, Viacheslav O Nikolaev, Katharina Völker, Birgit Gaßner, Robert Feil, Marc Freichel, Olaf Pongs and Michael Klaiber

Citation: BMC Pharmacology 2011 11(Suppl 1):O28

Content type: Oral presentation

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cGMP modulates stem cells differentiation to neurons in brain in vivo pathological implications

Authors: Ulises Gómez-Pinedo, Regina Rodrigo, Omar Cauli, Andrea Cabrera-Pastor, Sonia Herraiz, Jose-Manuel Garcia-Verdugo, Begoña Pellicer, Antonio Pellicer and Vicente Felipo

Citation: BMC Pharmacology 2011 11(Suppl 1):O29

Content type: Oral presentation

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BNP signaling is crucial for embryonic stem cell proliferation

Authors: Ikuo Tooyama and Essam M Abdelalim

Citation: BMC Pharmacology 2011 11(Suppl 1):O30

Content type: Oral presentation

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Protein kinase G type-I phosphorylates c-Src at serine-17 and promotes cell survival, proliferation and attachment in human mesothelioma and non-small cell lung cancer cells

Authors: Ronald R Fiscus and Mary G Johlfs

Citation: BMC Pharmacology 2011 11(Suppl 1):O31

Content type: Oral presentation

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Vasoprotection by heme oxygenase-1: interactions with soluble guanylate cyclase

Authors: William Durante

Citation: BMC Pharmacology 2011 11(Suppl 1):O32

Content type: Oral presentation

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NO resistance in angiotensin II–induced hypertension is associated with S-nitrosation of soluble guanylyl cyclase

Authors: Pierre-Antoine Crassous, Samba Couloubaly, Padma Baskaran, Zongmin Zhou, Andreas Papapetropoulos, David D Kim, Xavier Fioramonti, Walter N Durán and Annie Beuve

Citation: BMC Pharmacology 2011 11(Suppl 1):O33

Content type: Oral presentation

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Cyclic CMP and cyclic UMP: new (old) second messengers

Authors: Roland Seifert, Kerstin Beste, Heike Burhenne, Ulrike Voigt, Sabine Wolter, Andreas Hammerschmidt, Daniel Reinecke, Peter Sandner, Andreas Pich, Frank Schwede, Hans G Genieser and Volkhard Kaever

Citation: BMC Pharmacology 2011 11(Suppl 1):O34

Content type: Oral presentation

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Role of cGMP/PKG in fat tissue

Authors: Alexander Pfeifer

Citation: BMC Pharmacology 2011 11(Suppl 1):O35

Content type: Oral presentation

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Additional stimulation of sGC on top of standard treatment with ARB`s may offer a new therapeutic approach for the treatment of diabetic nephropathy resistant to ARB treatment alone

Authors: Markus Alter, Ina Ott, Karoline von Websky, Oleg Tsuprykov, Yuliya Sharkovska, Katharina Krause-Relle, Jens Raila, Andrea Henze, Axel Kretschmer, Johannes-Peter Stasch and Berthold Hocher

Citation: BMC Pharmacology 2011 11(Suppl 1):P1

Content type: Poster presentation

Published on: 1 August 2011
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Treatment with CBA-NP a novel chimeric natriuretic peptide attenuates cardiorenal fibrosis and improves diastolic dysfunction in diabetic rat model

Authors: Syed Ameenuddin, Elise A Oehler, John C Burnett Jr and Horng H Chen

Citation: BMC Pharmacology 2011 11(Suppl 1):P2

Content type: Poster presentation

Published on: 1 August 2011
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Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis

Authors: Reshma S Baliga, Sarah L Trinder, Christopher J Scotton, Rachel C Chambers, Raymond J MacAllister and Adrian J Hobbs

Citation: BMC Pharmacology 2011 11(Suppl 1):P3

Content type: Poster presentation

Published on: 1 August 2011
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Signaling via guanylyl cyclase C: cGMP, Src and p21

Authors: Nirmalya Basu, Sayanti Saha and Sandhya S Visweswariah

Citation: BMC Pharmacology 2011 11(Suppl 1):P4

Content type: Poster presentation

Published on: 1 August 2011
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Comparison of different vasodilators, endothelin antagonist, PDE5 inhibitior and sGC stimulators, in an animal model of secondary pulmonary hypertension: effects on “desaturation”

Authors: Eva Maria Becker, Johannes-Peter Stasch, Martin Bechem and Hubert Truebel

Citation: BMC Pharmacology 2011 11(Suppl 1):P5

Content type: Poster presentation

Published on: 1 August 2011
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Conjoined NO-sensitive guanylyl cyclases

Authors: Sönke Behrends, Mareike Busker, Nadine Haase, Tobias Haase, Jan Krähling and Monika Linnenbaum

Citation: BMC Pharmacology 2011 11(Suppl 1):P6

Content type: Poster presentation

Published on: 1 August 2011
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Evidence for two catalytic centers and Mn²⁺ as physiological cofactor of soluble guanylyl cyclase

Authors: Kerstin Yvonne Beste, Johannes-Peter Stasch, Volkhard Kaever and Roland Seifert

Citation: BMC Pharmacology 2011 11(Suppl 1):P7

Content type: Poster presentation

Published on: 1 August 2011
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Targeting of soluble guanylyl cyclase limits infarct size in a model of acute myocardial infarction

Authors: Justin S Bice and Gary F Baxter

Citation: BMC Pharmacology 2011 11(Suppl 1):P8

Content type: Poster presentation

Published on: 1 August 2011
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Protein kinase G I alpha activates an anti-remodeling signaling pathway in the heart via an interaction with the MAPKKK mixed lineage kinase 3

Authors: Robert M Blanton, Eiki Takimoto, Angela Lane, Mark J Aronovitz, Richard H Karas, David A Kass and Michael E Mendelsohn

Citation: BMC Pharmacology 2011 11(Suppl 1):P9

Content type: Poster presentation

Published on: 1 August 2011
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Activation of heme-free soluble guanylate cyclase with cinaciguat has beneficial cardiorenal actions when added to furosemide in experimental heart failure

Authors: Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Johannes-Peter Stasch and John C Burnett Jr.

Citation: BMC Pharmacology 2011 11(Suppl 1):P10

Content type: Poster presentation

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Bioavailability of intravenous versus subcutaneous administration of the dual GC-A and GC-B designer natriuretic peptide cenderitide in healthy canines

Authors: Guido Boerrigter, Lisa C Costello-Boerrigter, Gail J Harty and John C Burnett Jr

Citation: BMC Pharmacology 2011 11(Suppl 1):P11

Content type: Poster presentation

Published on: 1 August 2011
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Quantitation of cyclic nucleotides in mammalian cells and in human urine by high-performance liquid chromatography/mass spectrometry

Authors: Heike Burhenne, Kim Tappe, Kerstin Beste, Ulrike Voigt, Corinna Spangler, Dimitrios Tsikas, Volkhard Kaever and Roland Seifert

Citation: BMC Pharmacology 2011 11(Suppl 1):P12

Content type: Poster presentation

Published on: 1 August 2011
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sGCα₁-deficient mice: a novel murine model of spontaneous primary open angle glaucoma

Authors: Emmanuel S Buys, Yu-Chieh Ko, Sarah Hayton, Alexander Jones, Laurel Tainsh, Ruiyi Ren, Andrea Giani, Emma Abernathy, Haiyan Gong, Douglas J Rhee, Peter Brouckaert, Meredith Gregory, Louis R Pasquale, Kenneth D Bloch and Bruce Ksander

Citation: BMC Pharmacology 2011 11(Suppl 1):P13

Content type: Poster presentation

Published on: 1 August 2011
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Genetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase α₁ deficient mice

Authors: Emmanuel S Buys, Michael J Raher, Andrew Kirby, Sarah R Hayton, Laurel T Tainsh, Patrick Y Sips, Peter Brouckaert, Mark J Daly and Kenneth D Bloch

Citation: BMC Pharmacology 2011 11(Suppl 1):P14

Content type: Poster presentation

Published on: 1 August 2011
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G-protein regulator LGN inhibits the activity of soluble guanylyl cyclase

Authors: Swati Chauhan, Iraida Sharina and Emil Martin

Citation: BMC Pharmacology 2011 11(Suppl 1):P15

Content type: Poster presentation

Published on: 1 August 2011
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5th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

BMC Pharmacology