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C-type natriuretic peptide is a bifurcation factor for sensory neurons

Authors: Hannes Schmidt, Agne Stonkute, René Jüttner, Doris Koesling, Andreas Friebe, Robert Feil, Franz Hofmann and Fritz G Rathjen

Citation: BMC Pharmacology 2009 9(Suppl 1):P64

Content type: Poster presentation Published on: 11 August 2009

This article is part of a Supplement: Volume 9 Supplement 1
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The novel NO redox sibling, nitroxyl (HNO), prevents cardiomyocyte hypertrophy and superoxide generation via cGMP

Authors: Rebecca Ritchie, Jennifer Irvine, Swati Gossain, Jane Love, John Horowitz and Barbara Kemp-Harper

Citation: BMC Pharmacology 2009 9(Suppl 1):P58

Content type: Poster presentation Published on: 11 August 2009

This article is part of a Supplement: Volume 9 Supplement 1
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Nitric oxide resistance at the platelet level: pathophysiology and therapeutic implications

Authors: John Horowitz, Yuliy Chirkov and Rebecca Ritchie

Citation: BMC Pharmacology 2009 9(Suppl 1):S16

Content type: Oral presentation Published on: 11 August 2009

This article is part of a Supplement: Volume 9 Supplement 1
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B-type natriuretic peptide single nucleotide polymorphism rs198389 is highly prevalent and impacts test characteristics of common assays

Authors: Lisa C Costello-Boerrigter, Guido Boerrigter, Syed Ameenuddin, Douglas W Mahoney, Joshua P Susser, Denise M Heublein, Margaret M Redfield, Richard J Rodeheffer, Timothy M Olson and John C Burnett Jr

Citation: BMC Pharmacology 2009 9(Suppl 1):P9

Content type: Poster presentation Published on: 11 August 2009

This article is part of a Supplement: Volume 9 Supplement 1
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Glycosylation of human receptor guanylyl cyclase C

Authors: Najla Arshad and Sandhya S Visweswariah

Citation: BMC Pharmacology 2009 9(Suppl 1):P1

Content type: Poster presentation Published on: 11 August 2009

This article is part of a Supplement: Volume 9 Supplement 1
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A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

Regulators of G protein signaling (RGSs) accelerate GTP hydrolysis by Gα subunits and profoundly inhibit signaling by G protein-coupled receptors (GPCRs). The distinct expression patterns and pathophysiologic ...

Authors: Rebecca A Roof, David L Roman, Samuel T Clements, Katarzyna Sobczyk-Kojiro, Levi L Blazer, Shodai Ota, Henry I Mosberg and Richard R Neubig

Citation: BMC Pharmacology 2009 9:9

Content type: Research article Published on: 22 May 2009
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Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by hamartomatous growths in the brain, skin, kidneys, lungs, and heart, which lead to significant morbidity. T...

Authors: Nancy Lee, Chelsey L Woodrum, Alison M Nobil, Aubrey E Rauktys, Michael P Messina and Sandra L Dabora

Citation: BMC Pharmacology 2009 9:8

Content type: Research article Published on: 15 April 2009
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N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes

While doxorubicin (DOX) is widely used in cancer chemotherapy, long-term severe cardiotoxicity limits its use. This is the first report of the chemoprotective efficacy of a relatively new thiol antioxidant, N-...

Authors: Rong Shi, Chuan-Chin Huang, Robert S Aronstam, Nuran Ercal, Adam Martin and Yue-Wern Huang

Citation: BMC Pharmacology 2009 9:7

Content type: Research article Published on: 15 April 2009
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Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells

The quaking homolog, KH domain RNA binding (mouse) (QKI) is a candidate gene for schizophrenia. Disturbed QKI mRNA expression is observed in the prefrontal cortex of patients, and some of these changes correlate ...

Authors: Lin Jiang, Peter Saetre, Elena Jazin and Eva Lindholm Carlström

Citation: BMC Pharmacology 2009 9:6

Content type: Research article Published on: 31 March 2009
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Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats

Diclofenac is a nonsteroidal anti-inflammatory drug which is available as prescription (RX) and over-the-counter (OTC) medication for the systemic and topical treatment of painful and inflammatory conditions s...

Authors: A Schweitzer, N Hasler-Nguyen and J Zijlstra

Citation: BMC Pharmacology 2009 9:5

Content type: Research article Published on: 16 March 2009
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residues implicated in the formation K⁺ and Na⁺ ion channels effector toxins

K⁺ and Na⁺ channel toxins constitute a large set of polypeptides, which interact with their ion channel targets. These polypeptides are classified in two different structural groups. Recently a new structural gro...

Authors: Rima Soli, Belhassen Kaabi, Mourad Barhoumi, Mohamed El-Ayeb and Najet Srairi-Abid

Citation: BMC Pharmacology 2009 9:4

Content type: Research article Published on: 10 March 2009
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The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis

Treatment of head lice using physically acting preparations based on silicones is currently replacing insecticide use due to widespread resistance to neurotoxic agents. It has been postulated that some product...

Authors: Ian F Burgess

Citation: BMC Pharmacology 2009 9:3

Content type: Research article Published on: 20 February 2009
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AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts

Pluripotency, the property of a cell to differentiate into all cellular types of a given organism, is central to the development of stem cell-based therapies and regenerative medicine. Stem cell pluripotency i...

Authors: Luigi Adamo, Yuzhi Zhang and Guillermo García-Cardeña

Citation: BMC Pharmacology 2009 9:2

Content type: Research article Published on: 12 February 2009
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Conformational changes in α7 acetylcholine receptors underlying allosteric modulation by divalent cations

Allosteric modulation of membrane receptors is a widespread mechanism by which endogenous and exogenous agents regulate receptor function. For example, several members of the nicotinic receptor family are modu...

Authors: James T McLaughlin, Sean C Barron, Jennifer A See and Robert L Rosenberg

Citation: BMC Pharmacology 2009 9:1

Content type: Research article Published on: 13 January 2009
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Flexible modulation of agonist efficacy at the human A₃ adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000

A series of 1H-imidazo- [4,5-c]quinolin-4-amine derivatives, represented by LUF6000 (N-(3,4-dichloro-phenyl)-2-cyclohexyl-1H-imidazo [4,5-c]quinolin-4-amine), are allosteric modulators of the human A₃ adenosine r...

Authors: Zhan-Guo Gao, Kai Ye, Anikó Göblyös, Adriaan P IJzerman and Kenneth A Jacobson

Citation: BMC Pharmacology 2008 8:20

Content type: Research article Published on: 12 December 2008
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Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1

The activator protein-1 (AP-1) family of transcription factors contributes to regulation of numerous genes involved in proliferation, apoptosis, and tumorigenesis. A wide array of stimuli can activate AP-1, in...

Authors: Lorraine M Deck, Lucy A Hunsaker, Amanda M Gonzales, Robert A Orlando and David L Vander Jagt

Citation: BMC Pharmacology 2008 8:19

Content type: Research article Published on: 10 November 2008
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Voriconazole and target-site penetration into human tissue

Authors: Stefan Weiler, Rosa Bellmann-Weiler, Stefan Dunzendorfer, Michael Joannidis and Romuald Bellmann

Citation: BMC Pharmacology 2008 8(Suppl 1):A57

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Effect of antioxidants on ocular blood flow and endothelial function in an endotoxin-induced inflammatory model in humans

Authors: Berthold Pemp, Elżbieta Polska, Alexander Minichmayr, Katharina Karl, Michael Lasta, Gerhard Garhöfer, Michael Wolzt and Leopold Schmetterer

Citation: BMC Pharmacology 2008 8(Suppl 1):A55

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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In vivo profile of the human leukocyte microRNA response to endotoxemia

Authors: Wolfgang M Schmidt, Alexander O Spiel, Bernd Jilma, Michael Wolzt and Markus Müller

Citation: BMC Pharmacology 2008 8(Suppl 1):A53

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Targeting sphingosine kinase 1 with LNA oligonucleotides in gastric cancer

Authors: Thorsten Füreder, Doris Hoeflmayer, Bo Hansen and Volker Wacheck

Citation: BMC Pharmacology 2008 8(Suppl 1):A51

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of ¹¹C- and ¹⁴C-labelled verapamil in healthy volunteers

Authors: Claudia C Wagner, Marie Simpson, Graham Lappin, Rudolf Karch, Aiman Abrahim, Thomas Feurstein, Martin Bauer, Markus Zeitlinger, Kurt Kletter, Markus Müller and Oliver Langer

Citation: BMC Pharmacology 2008 8(Suppl 1):A49

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Calcium channel blockers reduce the antiplatelet effect of clopidogrel

Authors: Jolanta M Siller-Matula, Irene Lang, Günter Christ and Bernd Jilma

Citation: BMC Pharmacology 2008 8(Suppl 1):A47

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Selective serotonin reuptake inhibitors induce cell death via the unfolded protein response

Authors: Christina Glöckel, Patrick Thurner and Michael Freissmuth

Citation: BMC Pharmacology 2008 8(Suppl 1):A45

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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ARNO/cytohesin-2 regulates desensitization of the A_2A adenosine receptor in rat pheochromocytoma cells

Authors: Ingrid Gsandtner, Simon Keuerleber, Patrick Thurner and Oliver Kudlacek

Citation: BMC Pharmacology 2008 8(Suppl 1):A43

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Efforts to induce cardiac electrophysiological properties in skeletal myoblasts in vitro

Authors: Xaver Koenig, Eva Zebedin-Brandl, Markus Mille, Michael Schnürch, Moumita Koley, Marko D Mihovilovic, Rene Cervenka, Hannes Todt and Karlheinz Hilber

Citation: BMC Pharmacology 2008 8(Suppl 1):A41

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Long-term depression-like effect of a single immune challenge in neuropeptide Y Y₂ and Y₄ receptor knockout mice

Authors: Evelin Painsipp, Herbert Herzog, Günther Sperk and Peter Holzer

Citation: BMC Pharmacology 2008 8(Suppl 1):A39

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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BK channels in Purkinje cell plasma membranes are concentrated in plasmerosomes at sites of hypolemmal cisternae

Authors: Walter A Kaufmann, Francesco Ferraguti, Yugo Fukazawa, Yu Kasugai, Ryuichi Shigemoto, Petter Laake, Joseph A Sexton, Peter Ruth, Georg Wietzorrek, Hans-Günther Knaus, Johan F Storm and Ole P Ottersen

Citation: BMC Pharmacology 2008 8(Suppl 1):A37

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Establishing a new mouse model for investigating the function of amygdala neurons in anxiety

Authors: Yvan Peterschmitt, Stefan Weger, Alexander Plauth, Regine Heilbronn, William Wisden, Günther Sperk and Werner Sieghart

Citation: BMC Pharmacology 2008 8(Suppl 1):A35

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Chronic administration of rotenone induces Parkinsonian symptoms and increases levels of nitric oxide in rat brain

Authors: Valentina Bashkatova, Mesbach Alam, Anatoly Vanin, Helmut Prast and Werner J Schmidt

Citation: BMC Pharmacology 2008 8(Suppl 1):A33

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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TRPC3 as a key player in electrical remodelling of atrial myocardium

Authors: Zora Saad, Petra Eder, Klaus Zorn-Pauly and Klaus Groschner

Citation: BMC Pharmacology 2008 8(Suppl 1):A31

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Synthesis, opioid receptor binding profile and SAR studies of 14-alkoxy-substituted indolo- and benzofuromorphinans

Authors: Alexander Staaf, Mariana Spetea, Harald Mittendorfer and Helmut Schmidhammer

Citation: BMC Pharmacology 2008 8(Suppl 1):A30

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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5-Benzyl substituted 14-methoxymetopon, a high affinity μ opioid receptor agonist with potent antinociceptive activity in mice

Authors: Mariana Spetea, Catalina-Roxana Bohotin and Helmut Schmidhammer

Citation: BMC Pharmacology 2008 8(Suppl 1):A29

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors

Authors: Muhammad F Asim, Catalina-Roxana Bohotin, Mariana Spetea and Helmut Schmidhammer

Citation: BMC Pharmacology 2008 8(Suppl 1):A28

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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STAT1 Ser727 – key regulator for NK cell-mediated cytotoxicity and tumor surveillance

Authors: Eva M Putz, Eva Zebedin-Brandl, Michaela Prchal, Thomas Decker, Pavel Kovarik and Veronika Sexl

Citation: BMC Pharmacology 2008 8(Suppl 1):A27

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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The far carboxy-terminus of the viral encoded chemokine receptor US28 binds to the sorting protein GASP-1 in vitro

Authors: Gerald P Parzmair, Wolfgang Platzer, Henry F Vischer, Martine J Smit and Maria Waldhoer

Citation: BMC Pharmacology 2008 8(Suppl 1):A26

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Statins induce apoptosis in human melanoma cells via multiple pathways

Authors: Christoph Minichsdorfer and Martin Hohenegger

Citation: BMC Pharmacology 2008 8(Suppl 1):A25

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Modulation of multidrug resistance proteins by statins in human neuroblastoma

Authors: Evelyn Sieczkowski, Peter Ambros and Martin Hohenegger

Citation: BMC Pharmacology 2008 8(Suppl 1):A24

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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RIM modulates Ca_V1.3 Ca²⁺ channels

Authors: Mathias Gebhart, Gabriella Juhasz-Vedres, Alexander Trockenbacher, Gerald J Obermair, Jutta Engel, Alexandra Koschak and Jörg Striessnig

Citation: BMC Pharmacology 2008 8(Suppl 1):A22

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Second-hit kinetic perturbations reveal structural features of the domain IV S6 segment associated with fast inactivation

Authors: René Cervenka, Touran Zarrabi, Xaver Koenig, Markus Mille, Karlheinz Hilber and Hannes Todt

Citation: BMC Pharmacology 2008 8(Suppl 1):A20

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Neurodegeneration and plastic changes in parahippocampal regions of the rat after kainic acid-induced epilepsy

Authors: Meinrad Drexel, Elke Kirchmair and Günther Sperk

Citation: BMC Pharmacology 2008 8(Suppl 1):A18

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Interactions of the G protein-coupled receptor-associated sorting proteins (GASP) 1 and 2 with the novel cannabinoid receptor GPR55

Authors: Julia Kargl, Nariman Balenga, Lene Martini, Jennifer Whistler and Maria Waldhoer

Citation: BMC Pharmacology 2008 8(Suppl 1):A16

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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The non-opioid analgesic flupirtine is a modulator of GABA_A receptors involved in pain sensation

Authors: Felicia Popovici, Manu Dorostkar and Stefan Boehm

Citation: BMC Pharmacology 2008 8(Suppl 1):A14

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Inhibition of growth factor mediated Akt phosphorylation in vascular smooth muscle cells by resveratrol: the contribution of SH2 domain containing phosphatase 2 and reactive oxygen species

Authors: Cornelia E Schreiner, Mario Kumerz, Atanas G Atanasov, Elke H Heiss and Verena M Dirsch

Citation: BMC Pharmacology 2008 8(Suppl 1):A12

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Effects of PGH₂ and PGD₂ on CRTH2 and DP receptors in primary cells and co-expressed in HEK293 cells

Authors: Miriam Sedej, Wolfgang Platzer, Anela Vukoja, Rufina Schuligoi, Bernhard A Peskar, Ákos Heinemann and Maria Waldhoer

Citation: BMC Pharmacology 2008 8(Suppl 1):A10

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Do the binding sites of substrates and tricyclic antidepressants overlap on the serotonin transporter?

Authors: Subhodeep Sarker and Ilka Steiner

Citation: BMC Pharmacology 2008 8(Suppl 1):A9

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y₁ receptors

Authors: Giri K Chandaka, Helmut Drobny and Stefan Boehm

Citation: BMC Pharmacology 2008 8(Suppl 1):A8

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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C-terminal mutation induces a folding defect in the serotonin transporter

Authors: Ali Elkasaby, Subhodeep Sarker and Herwig Just

Citation: BMC Pharmacology 2008 8(Suppl 1):A7

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Influence of estrous cycle on explorative behaviour of wild-type and prodynorphin knockout mice

Authors: Iris Rosskothen, Eduard Schunk, Stefano Gaburro, Nicolas Singewald, Herbert Herzog and Christoph Schwarzer

Citation: BMC Pharmacology 2008 8(Suppl 1):A6

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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Evaluation of Stat5 as a potential drug target in bcr/abl-induced leukemias

Authors: Andrea Hölbl, Christian Schuster, Boris Kovacic, Maria Hölzl, Sabine Fajmann, Florian Grebien, Lothar Hennighausen, Yongzhi Cui, Richard Moriggl, Hartmut Beug and Veronika Sexl

Citation: BMC Pharmacology 2008 8(Suppl 1):A4

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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US28 in melanoma growth

Authors: Elisabeth Moser, Joshi Shripad, Helmut Schaider and Maria Waldhoer

Citation: BMC Pharmacology 2008 8(Suppl 1):A2

Content type: Meeting abstract Published on: 5 November 2008

This article is part of a Supplement: Volume 8 Supplement 1
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BMC Pharmacology