- Meeting abstract
- Open Access
The effect of cetirizine, an H1 receptor antagonist, on bone modeling during orthodontic tooth movement in rats
BMC Pharmacology volume 9, Article number: A65 (2009)
We used three groups of Wistar rats: control group (n = 16), orthodontic appliance only group (n = 16) and cetirizine group (n = 16). Animals of the last two groups were fitted with a super-elastic closed coil spring appliance (F = 25 cN) between the upper first left molar and the upper incisors. Animals of the appliance only group were treated daily with saline and animals of the cetirizine group with 3 mg/kg of cetirizine, respectively. Tooth movement was measured weekly from day 0 to day 42. Animals of each group were sacrificed on day 42 and tissue samples were prepared for further analysis. Gene expression levels for bone turnover markers cathepsin K and osteocalcin were determined by means of RT-PCR. Alveolar bone volume, osteoblast and osteoclast volume were determined histomorphometrically.
Cetirizine decreased the amount of tooth movement from day 28 onwards (p < 0.01) and it also decreased osteoclast volume (p < 0.001). The increase in the alveolar bone volume was observed in the cetirizine group (p < 0.01) compared to the appliance only group. No significant difference was observed in osteoclast activity, osteoblast volume and osteoblast activity between the cetirizine and the appliance only groups.
Cetirizine influences bone modeling, mainly by inhibiting bone resorption. Therefore, H1 receptor antagonists therapy is supposed to interfere with orthodontic treatment.
Seeman E: Structural basis of growth-related gain and age-related loss of bone strength. Rheumatology. 2008, 47 (Suppl 4): iv2-iv8. 10.1093/rheumatology/ken177.
Lesclous P, Schramm F, Gallina S, Baroukh B, Guez D, Saffar JL: Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats. Exp Physiol. 2006, 9: 561-570. 10.1113/expphysiol.2006.033217.
Deyama Y, Kikuiri T, Ohnishi G, Feng YG, Takeyama S, Hatta M, Yoshimura Y, Suzuki K: Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand by osteoblasts. Biochem Biophys Res Commun. 2002, 298: 240-246. 10.1016/S0006-291X(02)02440-3.
Rights and permissions
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Meh, A., Sprogar, Š., Marc, J. et al. The effect of cetirizine, an H1 receptor antagonist, on bone modeling during orthodontic tooth movement in rats. BMC Pharmacol 9 (Suppl 2), A65 (2009). https://doi.org/10.1186/1471-2210-9-S2-A65
- Bone Turnover Marker
- Orthodontic Treatment
- Tooth Movement