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Acute heart failure syndromes

Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalisation and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes [1].

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  1. 1.

    Gheorghiade M, Pang PS: Acute heart failure syndromes. J Am Coll Cardiol. 2009, 53: 557-573. 10.1016/j.jacc.2008.10.041.

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Correspondence to Mihai Gheorghiade.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gheorghiade, M. Acute heart failure syndromes. BMC Pharmacol 9, S13 (2009). https://doi.org/10.1186/1471-2210-9-S1-S13

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Keywords

  • Clinical Trial
  • Health Care
  • Heart Failure
  • Mortality Rate
  • Event Rate