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Open Access

Acute heart failure syndromes

BMC Pharmacology20099(Suppl 1):S13

Published: 11 August 2009


Clinical TrialHealth CareHeart FailureMortality RateEvent Rate

Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalisation and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes [1].

Authors’ Affiliations

Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, USA


  1. Gheorghiade M, Pang PS: Acute heart failure syndromes. J Am Coll Cardiol. 2009, 53: 557-573. 10.1016/j.jacc.2008.10.041.View ArticlePubMedGoogle Scholar


© Gheorghiade; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.