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Molecular steps in sGC activation
© Boon et al; licensee BioMed Central Ltd. 2007
Published: 25 July 2007
In addition, further structural studies have delineated the conformational changes that take place upon activation of an NO sensor prokaryotic H-NOX domain. Relevance of these conformational changes to sGC is being investigated. A recnt report bearing on this has appeared .
NO binding to the heme remains as a key molecular activation step; however, it has become clear that activation and deactivation are regulated in a complex manner [8–10]. Evidence suggests regulation by an additional NO binding site and allosteric regulation by ATP and GTP.
We gratefully acknowledge financial support from the NIH (GM070671), and the Aldo DeBenedictis Fund.
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