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Receptor guanylyl cyclases in mammalian olfaction: from genes to function
BMC Pharmacology volume 9, Article number: S45 (2009)
The contributions of guanylyl cyclases to sensory signaling in the olfactory system have been unclear. Recently, studies of a specialized subpopulation of olfactory sensory neurons (OSNs) located in the main olfactory epithelium have provided important insights into the neuronal function of one receptor guanylyl cyclase, GC-D. Gene-targeted mice expressing reporters such as β-galactosidase and green fluorescent protein in OSNs that normally express GC-D have allowed investigators to identify these neurons in situ, facilitating anatomical and physiological studies of this sparse neuronal population. The specific perturbation of GC-D function in vivo has helped to resolve the role of this guanylyl cyclase in the transduction of olfactory stimuli. Similar approaches could be useful for the study of the orphan receptor GC-G, which is expressed in another distinct subpopulation of sensory neurons located in the Grueneberg ganglion. This lecture will discuss the key findings that have reinvigorated the study of guanylyl cyclase function in the olfactory system.
Leinders-Zufall T, Cockerham RE, Michalakis S, Biel M, Garbers DL, Reed RR, Zufall F, Munger SD: Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci USA. 2007, 104: 14507-14512. 10.1073/pnas.0704965104.
Munger SD, Leinders-Zufall T, Zufall F: Subsystem organization of the mammalian sense of smell. Annu Rev Neurosci. 2009, 71: 115-140.
Zufall F, Munger SD: Receptor guanylyl cyclases in mammalian olfactory function. Mol Cell Biochem.
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Zufall, F. Receptor guanylyl cyclases in mammalian olfaction: from genes to function. BMC Pharmacol 9 (Suppl 1), S45 (2009). https://doi.org/10.1186/1471-2210-9-S1-S45
- Green Fluorescent Protein
- Sensory Neuron
- Physiological Study
- Sensory Signaling
- Neuronal Population