Volume 9 Supplement 1

4th International Conference of cGMP Generators, Effectors and Therapeutic Implications

Open Access

Receptor guanylyl cyclases in mammalian olfaction: from genes to function

BMC Pharmacology20099(Suppl 1):S45

https://doi.org/10.1186/1471-2210-9-S1-S45

Published: 11 August 2009

The contributions of guanylyl cyclases to sensory signaling in the olfactory system have been unclear. Recently, studies of a specialized subpopulation of olfactory sensory neurons (OSNs) located in the main olfactory epithelium have provided important insights into the neuronal function of one receptor guanylyl cyclase, GC-D. Gene-targeted mice expressing reporters such as β-galactosidase and green fluorescent protein in OSNs that normally express GC-D have allowed investigators to identify these neurons in situ, facilitating anatomical and physiological studies of this sparse neuronal population. The specific perturbation of GC-D function in vivo has helped to resolve the role of this guanylyl cyclase in the transduction of olfactory stimuli. Similar approaches could be useful for the study of the orphan receptor GC-G, which is expressed in another distinct subpopulation of sensory neurons located in the Grueneberg ganglion. This lecture will discuss the key findings that have reinvigorated the study of guanylyl cyclase function in the olfactory system.

Authors’ Affiliations

(1)
Department of Physiology, University of Saarland, School of Medicine

References

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Copyright

© Zufall; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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