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Open Access

Sildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice

  • Candace M Parchen1Email author,
  • Dao-Fu Dai2,
  • Justin M Percival3,
  • Monte Willis4,
  • Stanley C Froehner2 and
  • Joseph A Beavo1
BMC Pharmacology20099(Suppl 1):P53

https://doi.org/10.1186/1471-2210-9-S1-P53

Published: 11 August 2009

Background

Duchenne muscular dystrophy (DMD) is the most prevalent type of muscular dystrophy and is the result of an X-linked mutation in the dystrophin gene. The progression of skeletal muscle damage is rapid in DMD patients and cardiomyopathy soon follows. We have investigated whether or not sildenafil citrate, a phosphodiesterase 5 (PDE5) inhibitor, can be used to ameliorate the age-related cardiac dysfunction in dystrophin-null (mdx) mice, a mouse model of DMD.

Results

Using echocardiography, we show that chronic sildenafil treatment prevents several functional deficits in the cardiac performance of aged mdx mice. Sildenafil treatment also prevents cardiac fibrosis from developing. Not only does sildenafil prevent cardiac dysfunction, but it also reverses established cardiomyopathy when treatment starts in aged mdx mice. This is the first study to report a cardioprotective and reversal effect of PDE5 inhibition in aged mdx mice.

Conclusion

Overall, the data suggest that PDE5 inhibitors could be a useful treatment for the cardiomyopathy suffered by DMD patients.

Declarations

Acknowledgements

This work was supported by NIH grants DK21723 (JAB), NS059514 (SCF), MDA Development Grant (JMP) and Charley's Fund (SCF and JAB).

Authors’ Affiliations

(1)
Department of Pharmacology, University of Washington
(2)
Department of Pathology, University of Washington
(3)
Department of Physiology & Biophysics, University of Washington
(4)
Department of Pathology and Laboratory Medicine, University of North Carolina

Copyright

© Parchen et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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