Figure 2

Consensus phylogenetic tree built using all sequences (training dataset and test dataset). (a) A Simplified phylogenetic tree that displays three major clades labeled G1, G2, and G3. G2 is further subdivided into two groups S1 and S2. (b) Individual clades; G1, S1, S2, and G3. Symbols: – Training dataset sequences: black circle active on Na⁺ channel, black square active on K⁺ channel, black triangle birtoxin-like. – Test dataset sequences with known activity: (_Na⁺): active on Na⁺ channel, (_K⁺): active on K⁺ channel, birtoxin-like: _birtoxin-like.