Figure 2From: Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathwayEffect of psychotropic drugs on Wnt signaling activated by Wnt1 and LRP6. The TOPflash reporter was transfected into HEK293 cells with expression plasmids encoding Wnt1 and LRP6. After transfection, cells were treated with increasing concentrations of antipsychotic spiperone analogs for 24 h, as indicated. Then cells were harvested and luciferase activities were determined.Back to article page