Figure 1

A model of the α7 AChR extracellular domain. Ribbon cartoon showing two of the five subunits viewed from the outside. In the subunit to the left of the central interface (yellow), the outer β sheet in is highlighted in orange, the transition zone E⁴⁴ residue is orange, and the W¹⁴⁸ residue is shown in gray to identify the ACh binding pocket (Zhong et. al., 1998). The subunit to the right shows a view of the inner sheet (teal), and other residues targeted in this study. The sequence surround mutants characterized in this study is shown beneath the cartoon: M³⁷, M⁴⁰ cyan; N⁵² green; N¹⁷⁰ blue; E¹⁷² purple.