Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats

Table 2 Effect of CsA and sulphated polysaccharides on the antioxidant defense system in the hepatic tissues

Antioxidants	Group I (Control)	Group II (CsA)	Group III (Sulphated polysaccharides)	Group IV (CsA + sulphated polysaccharides)
Enzymic antioxidants
SOD	8.73 ± 0.96	6.52 ± 0.79 a***	8.75 ± 0.87	8.54 ± 0.94 b***
CAT	342.67 ± 41.40	260.50 ± 28.63 a***	341.92 ± 41.31	329.84 ± 32.65 b**
GPx	18.76 ± 1.86	12.38 ± 1.63 a***	19.01 ± 2.09	18.12 ± 1.79b***
Non-enzymic antioxidants
GSH	16.89 ± 1.86	12.53 ± 1.24 a***	16.82 ± 2.00	16.47 ± 1.81 b***
Vitamin C	1.92 ± 0.21	1.26 ± 0.15 a***	1.96 ± 0.19	1.67 ± 0.20 ab*
Vitamin E	0.84 ± 0.08	0.56 ± 0.07 a***	0.89 ± 0.09	0.79 ± 0.08 b***

Values are expressed as mean ± S.D. for six animals in each group.
Units of enzyme activity: SOD: Units/mg protein, one unit is equal to the amount of enzyme that inhibits the auto-oxidation reaction by 50%; CAT: μmoles of H₂O₂ consumed/min/mg protein; GPx: μg of reduced GSH consumed/min/mg protein; GSH, vitamin C and vitamin E: μg/mg protein.
Comparisons are made between: a-Group I and Groups II, III, IV; b-Group II and Group IV. The symbols (***), (**) and (*) represent statistical significance at P < 0.001, P < 0.01 and P < 0.05, respectively.