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Table 3 Statistical analysis for AUC0-t(last), AUC0-∞ and Cmax

From: Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers

Parameter Ratio Estimate 90%CI
AUC0-t(last) E/A 1.0241 0.9959; 1.0531
  E/B 1.0058 0.9700; 1.0430
AUC0-∞ E/A 1.0240 0.9958; 1.0529
  E/B 1.0060 0.9704; 1.0430
Cmax E/A 1.1084 1.0542; 1.1852
  E/B 1.1732 1.1058; 1.2447
Parameter Difference Estimate 90%CI
tmax E – A -0.6250 -0.8750; -0.3750
  E – B -0.6875 -1.000; -0.3750
  1. Statistical analysis by treatment pair (parametric analysis, pharmacokinetic population; N = 60). "A" refers to Nurofen® forte, "B" refers to Migränin® and "E" refers to Eudorlin® extra. CI: confidence interval.