Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration

Table 3 Concentration of desipramine and desmethyldesipramine (DDMI) in the cerebellum of rats at the end of the hypothermic experiments.

Rats that had been treated either acutely or for four days with desipramine (same animals as those in Fig. 4–5) were decapitated under isoflurane anesthesia at the completion of the hypothermic experiment (3 to 4 h after giving brimonidine) and the desipramine concentration ± S.E.M. in the cerebellum was determined. The time given in the table is the time after the last dose of desipramine. Thus the 27 hour data in this table, for example, come from the same animals as the 24 hour data in Fig. 4. The number of rats in each group is given in the legends for Fig. 1–3.
ND: Not determined, but assumed to be essentially 0.