Skip to main content

Table 3 Concentration of desipramine and desmethyldesipramine (DDMI) in the cerebellum of rats at the end of the hypothermic experiments.

From: Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration

Adult Rats Post-natal Day 9–12 Rats
Time
(h)
Desipramine
(ng/g)
DDMI
(ng/g)
Desipramine + DDMI
(ng/g)
Time
(h)
Desipramine
(ng/g)
DDMI
(ng/g)
Desipramine + DDMI
(ng/g)
Acute Treatment Acute Treatment
3 1880 ± 130 430 ± 95 2310 3 1500 ± 140 100 ± 17 1600
Repeated Treatment Repeated Treatment
17 4010 ± 640 2710 ± 150 6720 18 3750 ± 190 530 ± 31 4280
27 220 ± 50 510 ± 79 730 28 2550 ± 480 440 ± 16 2540
52 12 ± 12 34 ± 34 46 67 82 ± 50 55 ± 18 137
100 ND ND ND 100 18 ± 10 2 ± 2 20
  1. Rats that had been treated either acutely or for four days with desipramine (same animals as those in Fig. 45) were decapitated under isoflurane anesthesia at the completion of the hypothermic experiment (3 to 4 h after giving brimonidine) and the desipramine concentration ± S.E.M. in the cerebellum was determined. The time given in the table is the time after the last dose of desipramine. Thus the 27 hour data in this table, for example, come from the same animals as the 24 hour data in Fig. 4. The number of rats in each group is given in the legends for Fig. 13.
  2. ND: Not determined, but assumed to be essentially 0.