Figure 4

Brimonidine induced changes in rectal temperature after 4-days of desipramine treatment in adult rats. Rats were injected twice a day for four days with 10 mg/kg desipramine (DMI) or vehicle starting in either the morning or the evening. Measurements of rectal temperature were conducted the same time each morning 14, 24, 48 and 96 h after the last desipramine/water dose. The rectal temperature was taken immediately prior (0 time) to giving brimonidine (1.0 mg/kg) and then 30, 60, 90 and 120 min thereafter. Data points are the average change in rectal temperature from the zero time temperature for each group of rats. The number of rats used in the 14, 24, 48 and 96 h experiments were 4, 12,14 and 8 control and 4, 12, 13 and 7 desipramine treated rats, respectively. Change in temperature with drug concentration is statistically different (P < 0.05) 24 hr after the last dose. The change in rectal temperature with time is statistically significant (P < 0.001) for all experiments.