Figure 1

Brimonidine-induced decrease in rectal temperature in adult and post-natal day 13 rats. Upper panel: The change in rectal temperature of adult rats immediately before (0 time) brimonidine administration and 30, 60, 90 and (in some experiments) 120 min after brimonidine injection (i.p.) of 0, 0.1, 0.3, 0.6, 1, 1.5 or 2 mg/kg. The average rectal temperature for adult rats at time 0 was 35.1 ± 0.2°C and the number of rats at each dose is given in Table 1. Middle Panel:The change in rectal temperature of post-natal day 13 rats immediately before (0 time) brimonidine administration and 30, 60, 90, 120 and 135 min after brimonidine injection (i.p.) of 0, 0.1, 0.3, 0.6, 0.8 or 10 mg/kg with 3 to 6 rats per dose. The average rectal temperature at time 0 for post-natal day13 rats was 34.4 ± 0.2°C and the number of rats at each dose is given in Table 1. Lower Panel: Changes in rectal temperature in both adult and post-natal day 13 rats as a function of dose at 90 min. Data were analyzed using nonlinear regression analysis of an exponential decay equation. The two curves are statistically different using an F-test (P < 0.006). Error bars indicate S.E.M.