Volume 7 Supplement 2

13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)

Open Access

Changes in stereotyped behaviour following acute or repeated methylenedioxy-methamphetamine (MDMA) treatment

  • Susanna Szelényi1,
  • Ágnes Bajnogel-Orosz1,
  • Julia Timár1Email author,
  • Susanna Gyarmati1,
  • Melinda Sobor1, 2 and
  • Susanna Fürst1, 3
BMC Pharmacology20077(Suppl 2):A46

https://doi.org/10.1186/1471-2210-7-S2-A46

Published: 14 November 2007

Objective

In our previous experiments a decrease of the MDMA-induced 5-HT syndrome (HTS) was observed following repeated administration of the dextrorotatory (d) enantiomer of MDMA. The aim of the present study was to examine how the dopamine agonist-induced stereotyped behaviour (SB) alters following single or repeated d-MDMA treatment.

Methods

Wistar male rats were treated with single or repeated (4 times with 2 hours intervals) doses (10 mg/kg) of d-MDMA. Three, 7 and 14 days later the intensity of d-MDMA-induced HTS and SB was examined. The SB-inducing effect of d-amphetamine (AM) and apomorphine (APO) was also checked.

Results

(1) Following repeated administration of d-MDMA the intensity of MDMA-induced HTS decreased while that of SB increased. (2) Single dose pretreatment with d-MDMA did not influence the d-MDMA-induced HTS but enhanced the SB. (3) The d-AM-induced SB also increased while the APO-induced SB did not change.

Conclusion

A single dose of d-MDMA, which, in contrast to the repeated treatment, did not alter the 5-HT-related behaviour, may already result in development of DA sensitization.

Declarations

Acknowledgements

This work was supported by Hungarian grants OTKA K-60999 and ETT-441/2006.

Authors’ Affiliations

(1)
Department of Pharmacology and Pharmacotherapy, Semmelweis University
(2)
National Institute of Pharmacy
(3)
HAS-SE Neuropsychopharmacology Research Group

Copyright

© Szelényi et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.

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