Skip to main content

Changes in stereotyped behaviour following acute or repeated methylenedioxy-methamphetamine (MDMA) treatment

Objective

In our previous experiments a decrease of the MDMA-induced 5-HT syndrome (HTS) was observed following repeated administration of the dextrorotatory (d) enantiomer of MDMA. The aim of the present study was to examine how the dopamine agonist-induced stereotyped behaviour (SB) alters following single or repeated d-MDMA treatment.

Methods

Wistar male rats were treated with single or repeated (4 times with 2 hours intervals) doses (10 mg/kg) of d-MDMA. Three, 7 and 14 days later the intensity of d-MDMA-induced HTS and SB was examined. The SB-inducing effect of d-amphetamine (AM) and apomorphine (APO) was also checked.

Results

(1) Following repeated administration of d-MDMA the intensity of MDMA-induced HTS decreased while that of SB increased. (2) Single dose pretreatment with d-MDMA did not influence the d-MDMA-induced HTS but enhanced the SB. (3) The d-AM-induced SB also increased while the APO-induced SB did not change.

Conclusion

A single dose of d-MDMA, which, in contrast to the repeated treatment, did not alter the 5-HT-related behaviour, may already result in development of DA sensitization.

Acknowledgements

This work was supported by Hungarian grants OTKA K-60999 and ETT-441/2006.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Julia Timár.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Szelényi, S., Bajnogel-Orosz, Á., Timár, J. et al. Changes in stereotyped behaviour following acute or repeated methylenedioxy-methamphetamine (MDMA) treatment. BMC Pharmacol 7, A46 (2007). https://doi.org/10.1186/1471-2210-7-S2-A46

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/1471-2210-7-S2-A46

Keywords

  • Dopamine
  • Single Dose
  • Previous Experiment
  • Apomorphine
  • Repeated Administration