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Open Access

Changes in stereotyped behaviour following acute or repeated methylenedioxy-methamphetamine (MDMA) treatment

  • Susanna Szelényi1,
  • Ágnes Bajnogel-Orosz1,
  • Julia Timár1Email author,
  • Susanna Gyarmati1,
  • Melinda Sobor1, 2 and
  • Susanna Fürst1, 3
BMC Pharmacology20077(Suppl 2):A46

https://doi.org/10.1186/1471-2210-7-S2-A46

Published: 14 November 2007

Objective

In our previous experiments a decrease of the MDMA-induced 5-HT syndrome (HTS) was observed following repeated administration of the dextrorotatory (d) enantiomer of MDMA. The aim of the present study was to examine how the dopamine agonist-induced stereotyped behaviour (SB) alters following single or repeated d-MDMA treatment.

Methods

Wistar male rats were treated with single or repeated (4 times with 2 hours intervals) doses (10 mg/kg) of d-MDMA. Three, 7 and 14 days later the intensity of d-MDMA-induced HTS and SB was examined. The SB-inducing effect of d-amphetamine (AM) and apomorphine (APO) was also checked.

Results

(1) Following repeated administration of d-MDMA the intensity of MDMA-induced HTS decreased while that of SB increased. (2) Single dose pretreatment with d-MDMA did not influence the d-MDMA-induced HTS but enhanced the SB. (3) The d-AM-induced SB also increased while the APO-induced SB did not change.

Conclusion

A single dose of d-MDMA, which, in contrast to the repeated treatment, did not alter the 5-HT-related behaviour, may already result in development of DA sensitization.

Declarations

Acknowledgements

This work was supported by Hungarian grants OTKA K-60999 and ETT-441/2006.

Authors’ Affiliations

(1)
Department of Pharmacology and Pharmacotherapy, Semmelweis University
(2)
National Institute of Pharmacy
(3)
HAS-SE Neuropsychopharmacology Research Group

Copyright

© Szelényi et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.

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