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Potential role of nociceptin and nocistatin in central regulation of gastric mucosal defense

  • Zoltán S Zádori1,
  • Nashwan Shujaa1,
  • Kornélia Tekes2 and
  • Klára Gyires1Email author
BMC Pharmacology20077(Suppl 2):A44

Published: 14 November 2007


Gastrointestinal TractCentral RegulationPotential RoleNaloxoneOpioid Receptor

Nociceptin (NOC) and Nocistatin (NS) are two neuropeptides derived from pre-pro-nociceptin. NOC is the endogenous ligand of the NOP receptor which exhibits marked structural analogy with opioid receptors. NOC has been reported to exert multiple effects in the gastrointestinal tract. The aims of this study were to compare the gastroprotective effects of NOC and NS and to analyse the mechanism of their gastroprotective action. Gastric mucosal damage was induced by acidified ethanol in rats. The compounds were given i.c.v. Both NOC and NS (0.2–5 nmol/rat) induced gastroprotective effects. Pre-administration of NS significantly decreased the effect of NOC, as well as the competitive antagonist J-113397 (70 nmol/rat) and vagotomy. The effect of both neuropeptides was reduced by naloxone (27 nmol/rat), naltrindole (4.8 nmol/rat), norbinaltorphimine (10 μg/rat) and β-FNA (20 nmol/rat). In conclusion, both NOC and NS initiate centrally a series of events which result in gastric mucosal defense. The gastroprotective effect of NOC and NS is likely to be mediated by endogenous opioids and conveyed to the periphery by a vagal-dependent mechanism.



This work was supported by ETT 529/2006.

Authors’ Affiliations

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary


© Zádori et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.