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Open Access

The hCMV chemokine receptor US28 prevents melanoma growth

  • Elisabeth Moser1,
  • Joshi Shripad2,
  • Ping Quan2,
  • Helmut Seidl1, 2,
  • Sasa Frank3,
  • Zhao-Jun Liu4,
  • Mizuho Fukunaga4,
  • Ronan McDaid4,
  • Helmut Kerl2,
  • Meenhard Herlyn4,
  • Helmut Schaider2 and
  • Maria Waldhoer1Email author
BMC Pharmacology20077(Suppl 2):A4

Published: 14 November 2007


MelanomaMelanoma CellMelanoma Cell LineHuman CytomegalovirusTumor Environment

The human cytomegalovirus (hCMV) encodes the G protein-coupled receptor (vGPCR) US28. This receptor signals constitutively and interacts with a broad range of chemokines, which are crucial to the pathophysiological significance and immunregulatory aspects of this receptor. Chemokines and their receptors have been shown to be key determinants of tumor growth and formation of metastases. US28 (and mutants thereof, i.e. US28R129A and US28Δ317) exert anti-tumorigenic effects in various melanoma cell lines by scavenging chemokines from the tumor environment. Here we show that in contrast to all other previously studied cell lines, US28 is expressed on the cell surface in the melanoma cell lines Sbcl2 and 451Lu. We suggest that GASP – the G protein-coupled receptor-associated sorting protein – which sorts US28 and many other GPCRs to the lysosomes is absent in melanoma cells. The absence of GASP might effect the tumor suppressing properties of US28.

Authors’ Affiliations

Department of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
Department of Dermatology, Medical University of Graz, Austria
Department of Medical Biochemistry and Microbiology, Medical University of Graz, Austria
The Wistar Institute, Philadelphia, USA


© Moser et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.