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The selective enhancer substance (-)-BPAP counteracts the histological and functional consequences of an experimental stroke in rats

The effect of the newly developed, up to the present most potent and selective enhancer substance, R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP], was studied in rats exposed to an experimental stroke. Permanent focal ischemia was induced by cortical photothrombosis in Wistar rats with Rose Bengal (20 mg/kg, i.v.), irradiated by a cold light source for 10 min. Rats were treated daily with (-)-BPAP (0.2 mg/kg, i.p.) for 3 days. The infarction was visualized with 2% TTC. The lesion size was evaluated by morphometry using image analysis software (AxioVison/Zeiss). The effect of (-)-BPAP on the learning ability of rats was measured in the shuttle box. The acquisition of a two-way conditioned avoidance reflex (CAR) was analyzed during 5 consecutive days. The rats were trained with 100 trials per day. The light-irradiation for 10 min after injection of Rose Bengal caused well-demarcated tissue damage in the cerebral cortex and decreased the performance of the lesioned rats in the shuttle box. (-)-BPAP treatment caused a statistically significant reduction of the infarct size (from 1.190 ± 0.096 mm2 to 0.256 ± 0.057 mm2; n = 18) and improved the performance of the rats (45.75 ± 15 to 75.67 ± 7.2; n = 12). The data are in excellent harmony with the series of papers which described the protective effect of (-)-BPAP in various types of enhancer-sensitive cultured cells.

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This work was supported by the Health Scientific Council (ETT 140/2003, ETT 606/2006).

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Correspondence to László Dénes.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dénes, L., Miklya, I. The selective enhancer substance (-)-BPAP counteracts the histological and functional consequences of an experimental stroke in rats. BMC Pharmacol 7, A32 (2007). https://doi.org/10.1186/1471-2210-7-S2-A32

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  • DOI: https://doi.org/10.1186/1471-2210-7-S2-A32

Keywords

  • Ischemia
  • Protective Effect
  • Light Source
  • Cerebral Cortex
  • Tissue Damage