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GPR55 is a novel cannabinoid receptor

Cannabinoids exert their effects by binding to G protein-coupled receptors (GPCRs). To date, two cannabinoid receptors have been cloned. The cannabinoid CB1 receptor is one of the most abundant GPCRs in the central nervous system and plays an important role in pain transmission, feeding and the rewarding effects of cannabis, whereas the CB2 receptor is predominantly found in immune cells. However, some effects of cannabinoids (especially in the vascular system) could not be attributed to either CB1 or CB2 receptor function. Here we present GPR55 as a putative novel cannabinoid receptor, since GPR55 signals, binds to and internalizes in the presence of synthetic cannabinoid ligands.

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Correspondence to Maria Waldhoer.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Balenga, N., Irving, A.J. & Waldhoer, M. GPR55 is a novel cannabinoid receptor. BMC Pharmacol 7 (Suppl 2), A3 (2007).

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