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Open Access

New mouse models for the analysis of cGMP signalling

  • Robert Feil1Email author,
  • Susanne Feil1,
  • Paul Franken2,
  • Yann Emmenegger2,
  • Mehdi Tafti2,
  • Karin Weindl3,
  • Sabine M Hölter3,
  • Wolfgang Wurst3,
  • Sonja Langmesser4,
  • Urs Albrecht4,
  • Michael Föller5,
  • Florian Lang5,
  • Silke Weber6 and
  • Franz Hofmann6
BMC Pharmacology20077(Suppl 1):S19

Published: 25 July 2007


Nitric OxideNatriuretic PeptideObject RecognitionNull MouseBehavioural Process

The second messenger cGMP mediates beneficial and detrimental effects of nitric oxide and natriuretic peptides. Studies with conventional knockout mice showed that the cGMP-dependent protein kinase type I (cGKI) transduces many acute effects of cGMP, such as smooth muscle relaxation and inhibition of platelet aggregation. However, the short life expectancy of cGKI null mice precludes the analysis of long-term processes in adult mice. Recently, we have generated conditional tissue-specific cGKI knockout and rescue mice that can be studied throughout adulthood. These mouse models have uncovered previously unknown functions of cGMP/cGKI signalling in complex behavioural processes, such as object recognition, social discrimination and the regulation of sleep-wake activity. Moreover, a novel role of cGKI in erythrocyte death will be discussed.

Authors’ Affiliations

Interfakultäres Institut für Biochemie, Universität Tübingen, Germany
Center for Integrative Genomics, University of Lausanne, Switzerland
Institute of Developmental Genetics, GSF, Neuherberg, Germany
Institute of Biochemistry, University of Fribourg, Switzerland
Department of Physiology, Universität Tübingen, Germany
Institut für Pharmakologie und Toxikologie, TU München, Germany


© Feil et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.