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  • Oral presentation
  • Open Access

New mouse models for the analysis of cGMP signalling

  • 1Email author,
  • 1,
  • 2,
  • 2,
  • 2,
  • 3,
  • 3,
  • 3,
  • 4,
  • 4,
  • 5,
  • 5,
  • 6 and
  • 6
BMC Pharmacology20077(Suppl 1):S19

https://doi.org/10.1186/1471-2210-7-S1-S19

Published: 25 July 2007

Keywords

  • Nitric Oxide
  • Natriuretic Peptide
  • Object Recognition
  • Null Mouse
  • Behavioural Process

The second messenger cGMP mediates beneficial and detrimental effects of nitric oxide and natriuretic peptides. Studies with conventional knockout mice showed that the cGMP-dependent protein kinase type I (cGKI) transduces many acute effects of cGMP, such as smooth muscle relaxation and inhibition of platelet aggregation. However, the short life expectancy of cGKI null mice precludes the analysis of long-term processes in adult mice. Recently, we have generated conditional tissue-specific cGKI knockout and rescue mice that can be studied throughout adulthood. These mouse models have uncovered previously unknown functions of cGMP/cGKI signalling in complex behavioural processes, such as object recognition, social discrimination and the regulation of sleep-wake activity. Moreover, a novel role of cGKI in erythrocyte death will be discussed.

Authors’ Affiliations

(1)
Interfakultäres Institut für Biochemie, Universität Tübingen, Germany
(2)
Center for Integrative Genomics, University of Lausanne, Switzerland
(3)
Institute of Developmental Genetics, GSF, Neuherberg, Germany
(4)
Institute of Biochemistry, University of Fribourg, Switzerland
(5)
Department of Physiology, Universität Tübingen, Germany
(6)
Institut für Pharmakologie und Toxikologie, TU München, Germany

Copyright

© Feil et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.

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