Volume 7 Supplement 1

3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications

Open Access

Vardenafil improves myocardial and endothelial function after cardiopulmonary bypass

  • Gábor Szabó1, 2Email author,
  • Gábor Veres1, 2,
  • Tamás Radovits1, 2,
  • Christiane Miesel-Gröschel1, 2 and
  • Matthias Karck1, 2
BMC Pharmacology20077(Suppl 1):P57

https://doi.org/10.1186/1471-2210-7-S1-P57

Published: 25 July 2007

Vardenafil is a novel PDE-5 blocker whit known vasodilatory properties via enhanced cGMP accumulation. In the present pre-clinical study, we investigated the effects of vardenafil pretreatment on myocardial and endothelial function in an experimental model of cardioplegic arrest and extracorporal circulation.

Twelve anesthetized dogs, underwent hypothermic cardiopulmonary bypass. 6 digs received vardenafil (30 μg/kg) prior initiation of cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started. Left ventricular end-systolic pressure volume relationship (Ees) was measured by a combined pressure-volume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descendent coronary blood flow (CBF) and endothelium-dependent vasodilatation to acetylcholine (ACH) were determined.

The admimistration of vardenafil led to a significantly better recovery (given as percent of baseline) of Ees 75 ± 5 % vs. 49 ± 5 %, p < 0.05. CBF and was also significantly higher in the Vardenafil group (58 ± 12 vs. 21 ± 3, ml/min, p < 0.05). ACH resulted in a significantly higher increase in CBF (80 ± 6% vs. 29 ± 5%, p < 0.05) in the Vardenafil group.

Application of vardenafil improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest.

Authors’ Affiliations

(1)
University of Heidelberg
(2)
Semmelweis University Medical School

Copyright

© Szabó et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.

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