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Vardenafil improves myocardial and endothelial function after cardiopulmonary bypass

Vardenafil is a novel PDE-5 blocker whit known vasodilatory properties via enhanced cGMP accumulation. In the present pre-clinical study, we investigated the effects of vardenafil pretreatment on myocardial and endothelial function in an experimental model of cardioplegic arrest and extracorporal circulation.

Twelve anesthetized dogs, underwent hypothermic cardiopulmonary bypass. 6 digs received vardenafil (30 μg/kg) prior initiation of cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started. Left ventricular end-systolic pressure volume relationship (Ees) was measured by a combined pressure-volume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descendent coronary blood flow (CBF) and endothelium-dependent vasodilatation to acetylcholine (ACH) were determined.

The admimistration of vardenafil led to a significantly better recovery (given as percent of baseline) of Ees 75 ± 5 % vs. 49 ± 5 %, p < 0.05. CBF and was also significantly higher in the Vardenafil group (58 ± 12 vs. 21 ± 3, ml/min, p < 0.05). ACH resulted in a significantly higher increase in CBF (80 ± 6% vs. 29 ± 5%, p < 0.05) in the Vardenafil group.

Application of vardenafil improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest.

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Correspondence to Gábor Szabó.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Szabó, G., Veres, G., Radovits, T. et al. Vardenafil improves myocardial and endothelial function after cardiopulmonary bypass. BMC Pharmacol 7, P57 (2007). https://doi.org/10.1186/1471-2210-7-S1-P57

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Keywords

  • Endothelial Function
  • Cardiopulmonary Bypass
  • Coronary Blood Flow
  • Pressure Volume
  • Extracorporal Circulation