Figure 1

CRC to Sildenafil (panel a), SILD-6f (panel b), SILD-6v (panel c) and SILD-6r (panel d) in E+ aortic rings (100 pM – 10 μM) precontracted with PE (1 μM). Curves were constructed in the absence (filled circles) or in the presence of L-NAME (100 μM; open circles) or ODQ (10 μM; filled squares) or BAY 41–2272 (30 nM; filled triangles). Experimental values of relaxation were calculated relative to the precontraction level. Data are the mean ± SEM of 4–6 experiments. *P < 0.05 compared to each control value.