Mapping the contribution of β3-containing GABAA receptors to volatile and intravenous general anesthetic actions

BMC Pharmacology

Table 2 Effects of propofol- and etomidate-induced anesthesia on baseline ECG parameters.

	Baseline		Propofol 30 mg/kg i.v.		Etomidate 10 mg/kg i.v		Propofol 180 mg/kg i.p		Etomidate 20 mg/kg i.p.		Alphaxalone 15 mg/kg i.v.
	wt	β3(N265M)	wt	β3(N265M)	wt	β3(N265M)	wt	β3(N265M)	wt	β3(N265M)	wt	β3(N265M)
RR(msec)	107 ± 3.6	108 ± 4.7	126 ± 8.5	138 ± 3.2*	205 ± 7***	172 ± 12.8**	283 ± 32**	211 ± 29**	217 ± 7.8	154 ± 12**	138 ± 7.6**	128 ± 6.3*
HRV (msec)	5.2 ± 0.8	5.4 ± 0.8	19.7 ± 3.7	16.8 ± 2.7	40.9 ± 3.3**	27 ± 4.3*#	14.3 ± 0.4*	16 ± 1*	13.2 ± 1.2*	28 ± 5.3*	25.7 ± 6.2*	19 ± 2.7*
QT(msec)	23.5 ± 0.6	19.7 ± 0.9	28.4 ± 1.5*	24.0 ± 1.4	27.4 ± 1.2*	26.0 ± 1.5*	29.8 ± 0.9***	26.8 ± 1.6	27.6 ± 0.9**	32.8 ± 3.7*	26.5 ± 1*	26.5 ± 1.3
QRS (msec)	12.2 ± 0.5	11.2 ± 0.5	13.6 ± 0.8	12.8 ± 1.6	14.6 ± 1*	13.7 ± 1.4	15.3 ± 0.9*	13.2 ± 1	14.2 ± 0.7**	14.6 ± 1.6	13.8 ± 1.1	13.2 ± 1
PQ(msec)	31.8 ± 1.3	32.2 ± 0.7	35.9 ± 2.5	36.4 ± 1.5*	40.4 ± 1.3***	37.4 ± 1.2**	47.8 ± 1.7**	43.8 ± 2**	46.2 ± 2**	44.4 ± 2**	37.3 ± 1.4*	35.8 ± 1.2*

All values are mean ± SEM.. Group sizes: propofol i.v.: wt n = 7, β3(N265M) n = 5, etomidate i.v.: wt n = 7, β3(N265M) n = 7, alphaxalone i.v.: wt n = 6, β3(N265M) n = 6, propofol i.p.: wt n = 4, β3(N265M) n = 6, etomidate i.p.: wt n = 5, β3(N265M) n = 5. * p < 0.05, ** p < 0.01, *** p < 0.001 compared to baseline, # p < 0.05 wild type compared to β3(N265M) mice. Treatment with all different vehicles alone did not lead to statistically significant changes of the ECG parameters recorded compared to baseline. Statistical comparison of drug values with vehicle values and of drug values with baseline values yields similar results.