BMC Pharmacology

Table 1 Effects of isoflurane-induced anesthesia on baseline ECG parameters.

From: Mapping the contribution of β3-containing GABA_A receptors to volatile and intravenous general anesthetic actions

	Baseline		Isoflurane 1.2%		Alphaxalone 15 mg/kg i.v.
	wt	β3(N265M)	wt	β3(N265M)	wt	β3(N265M)
RR(msec)	107 ± 3.6	108 ± 4.7	176 ± 129	128 ± 6.3	147 ± 9.7**	132 ± 2.9*
HRV(msec)	5.2 ± 0.8	5.4 ± 0.8	22 ± 2.4**	19 ± 2.7**	18.1 ± 4.1*	12.3 ± 1.6*
QT(msec)	23.5 ± 0.6	19.7 ± 0.9	26.6 ± 0.8*	24.9 ± 1*	26.6 ± 0.8	24.9 ± 1
QRS(msec)	12.2 ± 0.5	11.2 ± 0.5	14 ± 0.8*	13.0 ± 1.2	14 ± 0.8	13 ± 1.2
PQ(msec)	31.8 ± 1.3	32.2 ± 0.7	44.6 ± 1**	43.9 ± 0.7*	44.6 ± 1*	43.9 ± 0.8*

All values are mean ± SEM. RR inter-beat-interval. Group sizes: isoflurane: wt n = 7, β3(N265M) n = 7; alphaxalone i.v.: wt n = 6, β3(N265M) n = 6. * p < 0.05, ** p < 0.01, compared to baseline.

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