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Figure 3 | BMC Pharmacology

Figure 3

From: Mapping the contribution of β3-containing GABAA receptors to volatile and intravenous general anesthetic actions

Figure 3

Isoflurane-induced changes of ECG intervals. A, C. With application of isoflurane, QT and PQ intervals are prolonged. The prolongation is slightly less pronounced in β3(N265M) mice compared to wild type. B, D. Maximum change of PQ and QT after application of isoflurane compared to 1 hour baseline before application. For comparison, values for alphaxalone are displayed as well. Isoflurane: n = 7; alphaxalone i.v.: wt n = 6, β3(N265M) n = 6.

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BMC Pharmacology

ISSN: 1471-2210