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Figure 1 | BMC Pharmacology

Figure 1

From: Mapping the contribution of β3-containing GABAA receptors to volatile and intravenous general anesthetic actions

Figure 1

Isoflurane-induced heart rate depression. A. After application of isoflurane heart rate (HR) decreases in both wild-type and β3(N265M) mice. B. Maximum HR change after application of isoflurane compared to 1 hour baseline before application. For comparison, values for alphaxalone, a neurosteroid whose action at the GABAA receptor is not influenced by the β3(N265M) point mutation, are displayed as well [10]. Isoflurane: n = 7, alphaxalone i.v.: wt n = 6, β3(N265M) n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001.

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BMC Pharmacology

ISSN: 1471-2210