Figure 7

Blood and tissue rapamycin levels from nude mice treated with rapamycin or CCI-779. All mice were treated via IP injection at a dose of 8 mg/kg of indicated drug once per day and were euthanized either 2–4 hours or 24 hours after the final treatment was administered. Whole blood, brain, kidney, and tumor tissue were collected at necropsy. a) Blood, brain, and kidney rapamycin levels from cohorts treated with rapamycin or CCI-779 for four consecutive days and euthanized 2–4 hours after drug injection. b) Blood, brain, and kidney rapamycin levels from cohorts treated with rapamycin or CCI-779 for four consecutive days and euthanized 24 hours after drug injection. c) Tumor rapamycin levels from indicated cohorts treated with rapamycin or CCI-779 and euthanized 2–4 hours after drug injection. Rapa = rapamycin. This data is shown in table format with statistical analyses in Table 2.