Figure 4
Locations of the detected pockets superimposed on the tertiary structures of proteins or the amino acid sequence. (a) The main chain of Hormone_recep domain of RXRA [PDB:1MVC_A] is shown by a ribbon model and is colored grey. Atoms of the four detected pockets are shown as space-filling models, and each pocket is colored green (1,092Å3, 64%), blue (463Å3, 48%), light blue (169Å3, 82%), or yellow (152Å3, 78%), (the volume and the hydrophobic residue ratio of each pocket are shown in parentheses). The H12 region is shown in red. (b) Amino acid sequence of the Hormone_recep domain of RXRA [PDB:1MVC_A]. Amino acid residues comprising each pocket are color-coded as in (a). (c) Location of a pocket laid across CDK2 and CDKN1B on CDK2/CDKN1B/cyclin A complex [PDB:1JSU]. CDK2, CDKN1B, and cyclin A are shown in green, magenta, and grey, respectively. Atoms are colored blue composing of the pocket with the size of 714Å3 and the hydrophobic residue ratio of 50%. The location of the 'cyclin groove' [62] already studied as drug target is also shown. The figures were drawn using the CASTp [39].