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Figure 1 | BMC Pharmacology

Figure 1

From: An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome data

Figure 1

Schematic representation of our novel and integrative in silico system for discovering candidates for drug-targetable PPIs in binary PPI data. The system uses binary PPI data as an input and assesses each PPI based on three independent in silico investigations; detection of protein domains responsible for PPIs, finding SDC-binding pockets on protein surfaces, and evaluating similarities in the assignment of GO terms. By integrating the results of these three investigations, the system discovers candidates for drug-targetable PPIs.

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BMC Pharmacology

ISSN: 1471-2210