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Table 4 Number of molecules of drug per erythrocyte required for hemolysis of 2.6 × 107SRBC.

From: Cyclooxygenase expression is not required for release of arachidonic acid from cells by some nonsteroidal anti-inflammatory drugs and cancer preventive agents

Drug

μM required for lysis of 2.6 × 107/ml SRBC.

Molecules per erythrocyte

Tamoxifen

31 μM

7.3 × 108

Simvastatin

49 μM

1.1 × 109

Celecoxib

95 μM

2.2 × 109

Sulindac sulfide

178 μM

4.1 × 109

Indomethacin

1.5 mM

3.5 × 1010

Ibuprofen

2.75 mM

6.4 × 1010

  1. * = % Hemolysis of 6.5 × 107 SRBC (2.6 × 107 SRBC/ml).
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BMC Pharmacology

ISSN: 1471-2210