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Figure 1 | BMC Pharmacology

Figure 1

From: Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: Implication in inducible nitric oxide synthase expression

Figure 1

Effect of p38 MAPK inhibitor SB220025 on LPS-induced NO production. (A) Cells were stimulated with LPS (10 ng/ml) and treated with various concentrations of SB220025 1 h after LPS stimulation. After 24 h incubation the nitrite concentrations were measured as a marker of NO production. Values are mean ± S.E.M. (n = 6). (B) Cells were stimulated with LPS 1 h before addition of tested compounds. 24 h after addition of LPS the nitrite concentrations were measured as marker of NO production. Values are mean ± S.E.M. (n = 6). ***P < 0.001 compared with cells treated with LPS only.

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BMC Pharmacology

ISSN: 1471-2210