BMC Pharmacology

Table 9 K_i ratio values (K_i-D1/K_i-D2 and K_i-D2/K_i-5HT2A) of all test compounds except LE401

From: Dibenzazecine compounds with a novel dopamine/5HT_2A receptor profile and 3D-QSAR analysis

Compound	K_i-D1/K_i-D2	K_i-D2/K_i-5HT2A
Haloperidol	102 (100^a))	0.02 (0.05^a))
Clozapine	0.83 (1.58^a))	42.6 (19.95^a))
LE400	2.09	9.12
LE410	0.60	7.24
LE420	0.56	21.4
LE300	0.16	294
LE403	0.03	93.5
LE404	0.04	49.0
RMI-81582	0.05^a)	31.6^a)
SCH23390	0.0004^b)	50.0^c)

^a) Value is calculated from [6].
^b) Value is calculated from [33,34].
^c) Value is calculated from [34,35].
Further, data for SCH23390 and RMI-81582 are calculated from literature data. K_i values used are derived from radioligand binding studies.

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