BMC Pharmacology

Table 4 EC₅₀ and IC₅₀ values of reference compounds at D₁ and D_2L receptors in functional studies.

From: Dibenzazecine compounds with a novel dopamine/5HT_2A receptor profile and 3D-QSAR analysis

		Agonist		Antagonist
Assay	Receptor	SKF38393	Quinpirole	LE300	Haloperidol
[cAMP]	hD₁	33.0 ± 4.01		123 ± 31.1
	hD_2L		9.61 ± 3.31		1.54 ± 0.39
[Ca²⁺]	hD₁	24.5 ± 4.19		718 ± 168
	hD_2L		8.62 ± 2.66		0.30 ± 0.10

Data shown are EC₅₀/IC₅₀ values in nM ± SEM, n ≥ 3.

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