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Figure 12 | BMC Pharmacology

Figure 12

From: A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones

Figure 12

Actions of c.Sg are not inhibited by indomethacin, pertussis toxin pre-treatment or chelerythrine. A, B & C) Voltage records showing action potential firing properties in the presence of the three test treatments (indomethacin, pertussis toxin pre-treatment or chelerythrine) and multiple action potential firing evoked by 100 μg/mL c.Sg. Indomethacin (A) pertussis toxin pretreatment (B) and chelerythrine (C) all failed to prevent the switch to multiple firing after application of c.Sg to DRG neurones that previously fired single action potentials. At rest all neurones were held at -70 mV. D, E & F) Current traces illustrating voltage-activated K+ current activated at +60 mV by 100 ms voltage step commands from a holding potential of -70 mV. In the presence of the three test treatments (indomethacin, pertussis toxin pre-treatment or chelerythrine) c.Sg still induced multiple action potential firing and attenuated the voltage-activated K+ currents.

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BMC Pharmacology

ISSN: 1471-2210