Figure 5
Sensitivities to the neurosteroid pregnanolone. Modulation of GABA-induced currents by the neurosteroid pregnanolone in recombinant GABAA receptors expressed in Xenopus oocytes. A. Representative traces of pregnanolone (Preg, nM) modulation of GABA-induced currents (G, EC25 in μM) in different receptor subtypes. B. Pregnanolone dose-response curves in the presence of EC25 GABA (set to 100 %). The values are means ± standard errors (n = 6 for α3β1; n = 5 for α3β1γ2; n = 5 for α3β1θ; n = 6 for α3β1ε and n = 4 for α3β1θε receptors).