Table 1
Drug | aMuscarinic inhibition (pA2) | N | H1 receptor inhibition (~1/2 max-μM) | N |
|---|---|---|---|---|
Atropine | 9.4 ± 0.1 | 9 | ND | |
Methoctramine | 5.6 ± 0.1 | 11 | ND | |
4-DAMP | 8.6 ± 0.1 | 12 | ND | |
Diphenhydramine | 6.2 ± 0.1 | 15 | 0.3 | 12 |
Desloratadine | 6.4 ± 0.1 | 13 | 0.02 | 15 |
Hydroxyzine | 4.8 ± 0.1 | 11 | 0.14 | 12 |
Cetirizine | No effect (at 100 μM) | 13 | 0.12 | 14 |
Loratadine | No effect (at 30 μM) | 3 | 12 | 8 |
Fexofenadine | No effect (at 10 μM) | 3 | 0.25 | 11 |