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Table 1

From: Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport

Drug aMuscarinic inhibition (pA2) N H1 receptor inhibition (~1/2 max-μM) N
Atropine 9.4 ± 0.1 9 ND  
Methoctramine 5.6 ± 0.1 11 ND  
4-DAMP 8.6 ± 0.1 12 ND  
Diphenhydramine 6.2 ± 0.1 15 0.3 12
Desloratadine 6.4 ± 0.1 13 0.02 15
Hydroxyzine 4.8 ± 0.1 11 0.14 12
Cetirizine No effect (at 100 μM) 13 0.12 14
Loratadine No effect (at 30 μM) 3 12 8
Fexofenadine No effect (at 10 μM) 3 0.25 11
  1. a- all estimates for Ki are statistically different (p < 0.001) except diphenhydramine and desloratadine (p = 0.135)
  2. ND: Not done