Figure 3
A. The effects of desloratadine on gland cell responses to ACh are shown here. ΔIsc in response to ACh are inhibited by desloratadine as shown by a shift to higher concentrations of ACh in the presence of increasing concentrations of desloratadine. B. The concentration response relationships derived from data in A. desloratadine causes a parallel shift to the right in the concentration response relationships for ACh. C. Schild analysis of these data and those for diphenhydramine and hydroxyzine are presented.