Table 1 Baseline (pre-drug) cardiovascular variables. A set of target values that was representative of the sheep studied in our laboratory was compiled from previous measurements and literature values as indicated. A set of parameter values for the final (Constrained-Frank-Starling-Baroreceptor) was derived (Table 2) that produced an internally consistent model that closely replicated these target values (also shown for comparison).
Variable | Name | Target Value | Target value origin | Model derived Value | Units |
|---|---|---|---|---|---|
Vblood | Blood volume | 3.5 | literature [13] | 3.5 | L |
CVP | Central venous pressure | 2.00 | unpublished previous measurements and literature [20] | 2.00 | mmHg |
CPLv | Venous compliance | 0.45 | inferred from Vblood & CVP | 0.46 | L mmHg-1 |
MAP | Mean arterial pressure | 100 | previous measurements [21] | 100.9 | mmHg |
SVR | Systemic vascular resistance | 17.00 | calculated from CO & MAP | 17.0 | RU |
CO | Cardiac output | 6 | previous measurements [21] | 5.8 | L min-1 |
HR | Heart rate | 100 | previous measurements [21] | 98.3 | beats min-1 |
SV | Stroke volume | 0.06 | calculated from CO & HR | 0.059 | L |
CNT | Contractility | 3000 | previous measurements [9, 21] | 3000 | mmHg sec-1 |
S1 | Sympathetic tone – chronotropy | 1 | scaling factor only | 1 | dimensionless |
S2 | Sympathetic tone – Contractility | 1 | scaling factor only | 1 | dimensionless |