Figure 13From: Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs – method development and application to magnesium in sheepObserved and predicted results for Data set 2. The final kinetic-dynamic model developed using Data set 1 was used to predict the exogenous arterial magnesium concentrations (Cart,x), cardiac output (CO) and mean arterial pressure (MAP) for Data Set 2. The only change in the model between the two data sets was to increase the duration of the infusion from 2 to 5 min. The observed data are shown as symbols, together with the upper and lower 95% confidence intervals of the data (dotted lines). The predictions of the model are shown by the solid lines.Back to article page