Effect of tolterodine and oxybutynin on BVC and MP in conscious rats utilized 5 days after catheter implantation. Data represent the mean (± S.E.) AUC change of BVC and MP calculated as reported in the Method Section. Tolterodine was i.v. administered at 0.1 (n = 7) and 0.3 (n = 7) mg/kg (upper panel). Oxybutynin was administered at 1 mg/kg (n = 7; lower panel). Corresponding open bars represent changes recorded in the vehicle groups (n = 7). Statistical significance was evaluated by ANOVA (and Dunnett's test).