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Table 4 The time- response relations between different anticancer drugs for cyto-toxic effects against leukemia cell line HL-60; N = 3, probimane, Pro; 5-fluorouracil, 5-Fu; doxorubicin, Dox; vincristine, VCR; ICRF-187, (+) stereo-isomer of razoxane

From: Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines

Compounds Concentrations Percentage inhibition %
  μM 24 h 48 h 72 h
Pro 10 75.6 78.5 75.9
5-Fu 2 65.8 53.5 51.1
Dox 4 78.3 72.4 72.3
VCR 2 65.4 59.0 57.1
ICRF-187 10 47.6 37.8 42.9
MST-16 10 47.8 5.6 0.0