Table 7 Antitumor effects of Pro on Lewis lung carcinoma in combination with daunorubicin or bleomycin: *Administration every 3 hours. Experimental term was 11 days
From: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
Compounds | Dosage | Schedule | Body weight | Tumor weight (g) | Tumor inhibitions |
|---|---|---|---|---|---|
mg/Kg | 1, 5, and 9 administration | g | % | ||
Control | -- | -- | 20.6/21.6 | 2.62 ± 0.08 | |
Pro | 20 | 3 times a day | 20.6/20.8 | 1.45 ± 0.07 | 44.6 |
Dau | 2 | 1 time a day | 20.6/20.0 | 1.14 ± 0.08 | 56.5 |
Ble | 15 | 1 time a day | 20.7/21.2 | 1.36 ± 0.08 | 48.1 |
Pro + Dau | 20 + 2 | 3 times/1 time a day | 20.6/20.9 | 1.07 ± 0.05 | 59.2 |
Pro + Ble | 20 + 15 | 3 times/1 time a day | 20.7/19.8 | 0.59 ± 0.04 | 77.5 |