Table 4 Antitumor effects of bisdioxopiperazines of different schedules on Lewis lung carcinoma: *Administration every 3 hours, 16 mice were included in each testing group. **p < 0.05 (treatment vs control), Experimental term was 11 days
From: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
Compounds | Dosage | Schedule | Tumor weight | Tumor inhibition |
|---|---|---|---|---|
mg/kg | 1, 5, 9 administrations | (g) | % | |
Control | -- | -- | 2.36 ± 0.05 | |
Razoxane | 80 | 1 time a day | 2.49 ± 0.05 | -5.5 |
Razoxane | 40 | 1 time a day | 2.32 ± 0.07 | 1.7 |
Razoxane | 20 | 1 time a day | 2.80 ± 0.06 | -18.6 |
Razoxane | 10 | 3 times a day* | 1.51 ± 0.04** | 36.0 |
Probimane | 20 | 3 time a day* | 1.19 ± 0.05** | 49.6 |