BMC Pharmacology

Table 1 HF diet induced changes in SD rats.

From: Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats

	Normal diet	HF diet
Triglyceride (mg/dL)
Prior to start	95.0 ± 8.7	115.6 ± 13.7
2 weeks diet	100.4 ± 7.6	446.2 ± 38.7**++
4 weeks diet	121.7 ± 9.1	388.1 ± 44.5**++
Free fatty acid (mEq/L)
Prior to start	0.36 ± 0.05	0.41 ± 0.04
2 weeks diet	0.38 ± 0.05	0.56 ± 0.04**++
4 weeks diet	0.24 ± 0.02	0.67 ± 0.06**++
Glucose (mg/dL)
Prior to start	166.8 ± 5.3	162.8 ± 4.3
2 weeks diet	170.0 ± 11.3	174.1 ± 2.5
4 weeks diet	176.6 ± 2.8	167.0 ± 4.0
Post-prandial insulin (ng/ml)
Prior to start	0.71 ± 0.11	1.06 ± 0.15
2 weeks diet	1.26 ± 0.29	2.72 ± 0.47**++
4 weeks diet	1.23 ± 0.22	2.39 ± 0.35**++
Insulin AUC during OGTT
4 weeks diet	241.6 ± 19.5	528.6 ± 84.9**
Glucose AUC during OGTT
4 weeks diet	7360 ± 416	7533 ± 496
Serum adiponectin (μg/ml)
Prior to start	3.59 ± 0.25	3.53 ± 0.25
2 weeks diet	3.64 ± 0.32	4.96 ± 0.41*
4 weeks diet	3.75 ± 0.40	4.35 ± 0.40

*p < 0.05 vs Before diet, **p < 0.01 vs Before diet, ++p < 0.01 vs Normal diet.

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